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Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3)

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PDHK3; [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial

Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3)
CCC D463
HGNC 8811
MGI 2384308
PubMed 22865452
RGD 1593276
UniProt Q15120
Wiki PDK3
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. PDK3 is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD463Mu01 Recombinant Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD463Mu01 Polyclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) WB; IHC; ICC; IP.
Assay Kits SED463Mu ELISA Kit for Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) ELISA Kit Customized Service Offer
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  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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  5. "Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase."J. Biol. Chem. 276:37223-37229(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Interaction between the individual isoenzymes of pyruvate dehydrogenase kinase and the inner lipoyl-bearing domain of transacetylase component of pyruvate dehydrogenase complex."Biochem. J. 366:129-136(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Characterization of testis-specific isoenzyme of human pyruvate dehydrogenase."J. Biol. Chem. 281:9688-9696(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta."J. Mol. Biol. 372:341-355(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance."J. Biol. Chem. 283:28106-28114(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Butyrate elicits a metabolic switch in human colon cancer cells by targeting the pyruvate dehydrogenase complex."Int. J. Cancer 128:2591-2601(2011) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Inactivation of the HIF-1alpha/PDK3 signaling axis drives melanoma toward mitochondrial oxidative metabolism and potentiates the therapeutic activity of pro-oxidants."Cancer Res. 72:5035-5047(2012) [PubMed] [Europe PMC] [Abstract]
  13. "Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex."EMBO J. 24:1763-1774(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Crystal structure of an asymmetric complex of pyruvate dehydrogenase kinase 3 with lipoyl domain 2 and its biological implications."J. Mol. Biol. 370:407-416(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol."Structure 15:992-1004(2007) [PubMed] [Europe PMC] [Abstract]
  16. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
  17. "A new locus for X-linked dominant Charcot-Marie-Tooth disease (CMTX6) is caused by mutations in the pyruvate dehydrogenase kinase isoenzyme 3 (PDK3) gene."Hum. Mol. Genet. 22:1404-1416(2013) [PubMed] [Europe PMC] [Abstract]