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Pyruvate Dehydrogenase Kinase Isozyme 2 (PDK2)

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PDHK2; [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial

Pyruvate Dehydrogenase Kinase Isozyme 2 (PDK2)
CCC D464
HGNC 8810
MGI 1343087
PubMed 16014356
RGD 69428
UniProt Q15119
Wiki PDK2
[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial is an enzyme encoded by the PDK2 gene. It codes for an isozyme of pyruvate dehydrogenase kinase.
To find human PDKs, Gudi et al. (1995) used oligonucleotide primers to screen a human liver cDNA library by PCR. The human PDK2 gene encodes a protein with a predicted molecular mass of 46,181 Da that shares 96% identity with that of the rat PDK2 gene. Northern blot analysis showed that the PDK2 message was found in many tissues, with the highest level in heart and skeletal muscle, intermediate levels in brain, kidney, pancreas and liver, and low levels in placenta and lung.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pyruvate Dehydrogenase Kinase Isozyme 2 (PDK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 2 (PDK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 2 (PDK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pyruvate Dehydrogenase Kinase Isozyme 2 (PDK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pyruvate Dehydrogenase Kinase Isozyme 2 (PDK2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD464Mu01 Recombinant Pyruvate Dehydrogenase Kinase Isozyme 2 (PDK2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD464Mu01 Polyclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 2 (PDK2) WB; IHC; ICC; IP.
Assay Kits SED464Mu ELISA Kit for Pyruvate Dehydrogenase Kinase Isozyme 2 (PDK2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pyruvate Dehydrogenase Kinase Isozyme 2 (PDK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 2 (PDK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 2 (PDK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pyruvate Dehydrogenase Kinase Isozyme 2 (PDK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pyruvate Dehydrogenase Kinase Isozyme 2 (PDK2) ELISA Kit Customized Service Offer
  1. "Diversity of the pyruvate dehydrogenase kinase gene family in humans."J. Biol. Chem. 270:28989-28994(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Insulin downregulates pyruvate dehydrogenase kinase (PDK) mRNA: potential mechanism contributing to increased lipid oxidation in insulin-resistant subjects."Mol. Genet. Metab. 65:181-186(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Facilitated interaction between the pyruvate dehydrogenase kinase isoform 2 and the dihydrolipoyl acetyltransferase."J. Biol. Chem. 278:33681-33693(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Pyruvate dehydrogenase kinase isoform 2 activity limited and further inhibited by slowing down the rate of dissociation of ADP."Biochemistry 43:13432-13441(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Ligand-induced effects on pyruvate dehydrogenase kinase isoform 2."J. Biol. Chem. 281:12568-12579(2006) [PubMed] [Europe PMC] [Abstract]
  9. "A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth."Cancer Cell 11:37-51(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta."J. Mol. Biol. 372:341-355(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Pivotal role of the C-terminal DW-motif in mediating inhibition of pyruvate dehydrogenase kinase 2 by dichloroacetate."J. Biol. Chem. 284:34458-34467(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Chronic CSE treatment induces the growth of normal oral keratinocytes via PDK2 upregulation, increased glycolysis and HIF1alpha stabilization."PLoS ONE 6:E16207-E16207(2011) [PubMed] [Europe PMC] [Abstract]
  13. "p53 negatively regulates transcription of the pyruvate dehydrogenase kinase Pdk2."Cancer Res. 72:560-567(2012) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  15. "Regulatory roles of the N-terminal domain based on crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands."Biochemistry 45:402-415(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]