5-Hydroxytryptamine Receptor 1B (HTR1B)
[Edit]5-HT1B; 5-HT1DB; HTR1D2; HTR1DB; S12; Serotonin Receptor 1B; Serotonin 1D beta receptor
The receptor acts on the CNS, where it induces presynaptic inhibition and behavioural effects. It also has vascular effects, such as pulmonary vasoconstriction.Blocking the 5-HT1B receptor increases the number of osteoblasts, bone mass, and the bone formation rate.
5-HT1B receptors are present in many parts of the human brain. The highest concentrations are found in the basal ganglia, striatum and the frontal cortex.The function of the receptor differs between the areas: in the frontal cortex it is believed to act as a terminal receptor, inhibiting the release of dopamine. In the striatum and the basal ganglia, the 5-HT1B receptor is thought to act as an autoreceptor, inhibiting the release of serotonin.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant 5-Hydroxytryptamine Receptor 1B (HTR1B) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to 5-Hydroxytryptamine Receptor 1B (HTR1B) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to 5-Hydroxytryptamine Receptor 1B (HTR1B) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for 5-Hydroxytryptamine Receptor 1B (HTR1B) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for 5-Hydroxytryptamine Receptor 1B (HTR1B) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant 5-Hydroxytryptamine Receptor 1B (HTR1B) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to 5-Hydroxytryptamine Receptor 1B (HTR1B) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to 5-Hydroxytryptamine Receptor 1B (HTR1B) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for 5-Hydroxytryptamine Receptor 1B (HTR1B) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for 5-Hydroxytryptamine Receptor 1B (HTR1B) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant 5-Hydroxytryptamine Receptor 1B (HTR1B) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to 5-Hydroxytryptamine Receptor 1B (HTR1B) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to 5-Hydroxytryptamine Receptor 1B (HTR1B) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for 5-Hydroxytryptamine Receptor 1B (HTR1B) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for 5-Hydroxytryptamine Receptor 1B (HTR1B) | ELISA Kit Customized Service Offer |
- "Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: a homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity."Biochem. Biophys. Res. Commun. 184:752-759(1992) [PubMed] [Europe PMC] [Abstract]
- "Cloning and expression of the human 5-HT1B-type receptor gene."Biochem. Biophys. Res. Commun. 185:517-523(1992) [PubMed] [Europe PMC] [Abstract]
- "Characterization of the human 5-hydroxytryptamine1B receptor."J. Biol. Chem. 267:5735-5738(1992) [PubMed] [Europe PMC] [Abstract]
- "Molecular cloning of a human serotonin receptor (S12) with a pharmacological profile resembling that of the 5-HT1D subtype."J. Biol. Chem. 267:7553-7562(1992) [PubMed] [Europe PMC] [Abstract]
- "Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta."Proc. Natl. Acad. Sci. U.S.A. 89:3630-3634(1992) [PubMed] [Europe PMC] [Abstract]
- "A human serotonin 1D receptor variant (5HT1D beta) encoded by an intronless gene on chromosome 6."Proc. Natl. Acad. Sci. U.S.A. 89:5522-5526(1992) [PubMed] [Europe PMC] [Abstract]
- "Cloning and pharmacological characterization of a novel human 5-hydroxytryptamine1D receptor subtype."Mol. Pharmacol. 42:439-444(1992) [PubMed] [Europe PMC] [Abstract]
- "Human-specific amino acid changes found in 103 protein-coding genes."Mol. Biol. Evol. 21:936-944(2004) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Human serotonin1B receptor expression in Sf9 cells: phosphorylation, palmitoylation, and adenylyl cyclase inhibition."Biochemistry 32:11727-11733(1993) [PubMed] [Europe PMC] [Abstract]
- "Serotonin 5-HT1B and 5-HT1D receptors form homodimers when expressed alone and heterodimers when co-expressed."FEBS Lett. 456:63-67(1999) [PubMed] [Europe PMC] [Abstract]
- "Triptan-induced contractile (5-HT1B receptor) responses in human cerebral and coronary arteries: relationship to clinical effect."Clin. Sci. 109:335-342(2005) [PubMed] [Europe PMC] [Abstract]
- "Serotonin receptors."Chem. Rev. 108:1614-1641(2008) [PubMed] [Europe PMC] [Abstract]
- "Serotonin receptors - from molecular biology to clinical applications."Physiol. Res. 60:15-25(2011) [PubMed] [Europe PMC] [Abstract]
- "Structural features for functional selectivity at serotonin receptors."Science 340:615-619(2013) [PubMed] [Europe PMC] [Abstract]
- "Structural basis for molecular recognition at serotonin receptors." Science 340:610-614(2013) [PubMed] [Europe PMC] [Abstract]
- "Identification of genetic variation in the human serotonin 1D beta receptor gene."Biochem. Biophys. Res. Commun. 205:1194-1200(1994) [PubMed] [Europe PMC] [Abstract]