5-Hydroxytryptamine Receptor 1D (HTR1D)

5-hydroxytryptamine (serotonin) receptor 1D is a 5-HT receptor, but also denotes the human gene encoding it. 5-HT_1D acts on the central nervous system, and affects locomotion and anxiety. It also induces vascular vasoconstriction in the brain. Ergotamine works primarily through the 5-HT_1B receptor, since the effect through the 5-HT_1D receptor is contrary to the mode of action of ergotamine, i.e. vasoconstriction.The serotonin 1D receptor was initially characterized by radioligand binding procedures using membranes derived from bovine caudate nucleus. The 5-HT-1D receptor is known to be a G protein-coupled receptor. Sumatriptan, an agent effective in the treatment of acute migraine, is the only ligand yet identified that is selective for the 5-HT-1D receptor.