5-Hydroxytryptamine Receptor 1E (HTR1E)

5-hydroxytryptamine (serotonin) 1E receptor (5-HT_1E) is a highly expressed human G-protein coupled receptor that belongs to the 5-HT1 receptor family (G_i-coupled serotonin receptor).The function of the 5-HT_1E receptor is unknown due to the lack of selective pharmacological tools, specific antibodies, and permissive animal models.^[5] The 5-HT_1E receptor gene lacks polymorphisms amongst humans (few mutations), indicating a high degree of evolutionary conservation of genetic sequence, which suggests that the 5-HT_1E receptor has an important physiological role in humans. It is hypothesized that the 5-HT_1E receptor is involved in the regulation of memory in humans due to the high abundance of receptors in the frontal cortex, hippocampus, and olfactory bulb, all of which are regions of the brain integral to memory regulation.