5-Hydroxytryptamine Receptor 3E (HTR3E)

HTR3E belongs to the ligand-gated ion channel receptor superfamily. This gene encodes a subunit E of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. Genes encoding subunits C, D and E form a cluster on chromosome 3. An alternative splice variant has been described but its full length sequence has not been determined. The HTR3E gene encodes a predicted protein of 471 amino acids including a 16-amino acid signal sequence, 4 transmembrane domains, and several potential glycosylation and phosphorylation sites. Sequence comparisons showed that HTR3C, HTR3D, and HTR3E share amino acid sequence identities of 64.