5-Hydroxytryptamine Receptor 1F (HTR1F)

MR77 was expressed at low levels throughout the brain, with the greatest expression in the cortex, hippocampus, and striatum. HeLa cells transfected with the MR77 gene exhibited inhibition of adenylate cyclase in response to serotonin. Human MR77 is 86% and 93% identical to rat MR77 at the nucleic acid and amino acid sequence levels, respectively. Its amino acid sequence showed the greatest similarity to HTR1E. VanDenBrink et al. (1998) mapped the HTR1F gene to 3p12. They investigated the presence of polymorphisms by SSCP analysis in 14 migraine patients who consistently responded well to sumatriptan, 12 patients who consistently experienced recurrence of the headache after initial relief, 12 patients with no response to sumatriptan, and 13 patients who consistently experienced chest symptoms after use of sumatriptan.