5-Hydroxytryptamine Receptor 2B (HTR2B)

is a 5-HT₂ receptor, but also denotes the human gene encoding it.The 5-HT₂ receptorsmediate many of the central and peripheral physiologic functions of serotonin. Cardiovascular effects include contraction of blood vessels and shape changes in platelets; central nervous system effects include neuronal sensitization to tactile stimuli and mediation of some of the effects of phenylisopropylamine hallucinogens. few highly selective 5-HT_2B receptor ligands have been discovered, although numerous potent non-selective compounds are known, particularly agents with concomitant 5-HT_2C binding. Research in this area has been limited due to the cardiotoxicity of 5HT_2B agonists, and the lack of clear therapeutic application for 5HT_2B antagonists, but there is still a need for selective ligands for scientific research.