≡

5-Hydroxytryptamine Receptor 3B (HTR3B)

[Edit]

5-HT3B; Serotonin Receptor 3B

5-Hydroxytryptamine Receptor 3B (HTR3B)
CCC D490
HGNC 5298
MGI 1861899
PubMed 18698232
RGD 61820
UniProt O95264
Wiki HTR3B
HTR3Bencodes subunit B of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. The authors determined that HTR3B cannot assemble as a homomeric HTR3 receptor but that heteromeric HTR3A/HTR3B receptors display a large single-channel conductance (16 pS), low permeability to calcium ions, and a current-voltage relationship resembling that of characterized neuronal HTR3 channels.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 5-Hydroxytryptamine Receptor 3B (HTR3B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 5-Hydroxytryptamine Receptor 3B (HTR3B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 5-Hydroxytryptamine Receptor 3B (HTR3B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 5-Hydroxytryptamine Receptor 3B (HTR3B) CLIA Kit Customized Service Offer
n/a ELISA Kit for 5-Hydroxytryptamine Receptor 3B (HTR3B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 5-Hydroxytryptamine Receptor 3B (HTR3B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 5-Hydroxytryptamine Receptor 3B (HTR3B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 5-Hydroxytryptamine Receptor 3B (HTR3B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 5-Hydroxytryptamine Receptor 3B (HTR3B) CLIA Kit Customized Service Offer
n/a ELISA Kit for 5-Hydroxytryptamine Receptor 3B (HTR3B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 5-Hydroxytryptamine Receptor 3B (HTR3B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 5-Hydroxytryptamine Receptor 3B (HTR3B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 5-Hydroxytryptamine Receptor 3B (HTR3B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 5-Hydroxytryptamine Receptor 3B (HTR3B) CLIA Kit Customized Service Offer
n/a ELISA Kit for 5-Hydroxytryptamine Receptor 3B (HTR3B) ELISA Kit Customized Service Offer
  1. "The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit."J. Biol. Chem. 274:30799-30810(1999) [PubMed] [Europe PMC] [Abstract]
  2. "The 5-HT3B subunit is a major determinant of serotonin-receptor function."Nature 397:359-363(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Tissue-specific alternative promoters of the serotonin receptor gene HTR3B in human brain and intestine."Gene 386:52-62(2007) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A cytoplasmic region determines single-channel conductance in 5-HT3 receptors."Nature 424:321-324(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Characterization of the novel human serotonin receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E."Mol. Pharmacol. 72:8-17(2007) [PubMed] [Europe PMC] [Abstract]
  7. "The identification of N-glycosylated residues of the human 5-HT3B receptor subunit: importance for cell membrane expression."J. Neurochem. 116:975-983(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Investigation of the human serotonin receptor gene HTR3B in bipolar affective and schizophrenic patients."Am. J. Med. Genet. B Neuropsychiatr. Genet. 131:1-5(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Mutational analysis of serotonin receptor genes: HTR3A and HTR3B in fibromyalgia patients."Clin. Rheumatol. 23:338-344(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Distinguishable haplotype blocks in the HTR3A and HTR3B region in the Japanese reveal evidence of association of HTR3B with female major depression."Biol. Psychiatry 60:192-201(2006) [PubMed] [Europe PMC] [Abstract]
  11. "A population-specific HTR2B stop codon predisposes to severe impulsivity."Nature 468:1061-1066(2010) [PubMed] [Europe PMC] [Abstract]