5-Hydroxytryptamine Receptor 6 (HTR6)

The receptor, also known as the 5-hydroxytryptamine (serotonin) receptor 6 (HTR6), is a protein which in humans is encoded by the HTR6 gene. The 5-HT₆ receptor is primarily expressed in the brain and is involved in glutamatergic and cholinergic neuronal activity. It is a potential target for drugs treating cognitive diseases, schizophrenia, anxiety and obesity.As the protein is a neuroreceptor it is possible that genetic variations in the gene would have an effect on brain, and research studies have investigated whether polymorphisms is associated with brain-related variables, such as neuropsychiatric disorders. For example, in 2004 one Chinese study reported an association between the C267T polymorphism and Alzheimer's disease.Others have studied the polymorphism in relation to Parkinson's disease.