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Acetylserotonin-O-Methyltransferase (ASMT)

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HIOMT; ASMTY; HIOMTY; Hydroxyindole O-methyltransferase

Acetylserotonin-O-Methyltransferase (ASMT)
CCC D496
HGNC 750
PubMed 24156411
RGD 708472
UniProt P46597
Wiki ASMT
N-Acetylserotonin O-methyltransferase is an enzyme that catalyzes the final reaction in melatonin biosynthesis, converting Normelatonin to melatonin. This reaction is embedded in the more general tryptophan metabolism pathway. The enzyme also catalyzes a second reaction in tryptophan metabolism: the conversion of 5-hydroxy-indoleacetate to 5-methoxy-indoleacetate.Acetylserotonin O-methyltransferase is an enzyme that is coded for by genes located on the PAR region of the X and Y chromosome, and is most abundantly found in the pineal gland and retina of humans. Although the exact structure of N- Acetylserotonin O-methyltransferase has yet to be determined by X-Ray diffraction, the crystal structure of the Maf domain of human N-Acetylserotonin O-methyltransferase-like protein has been found.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD496Hu01 Recombinant Acetylserotonin-O-Methyltransferase (ASMT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD496Hu01 Polyclonal Antibody to Acetylserotonin-O-Methyltransferase (ASMT) WB; IHC; ICC; IP.
MAD496Hu21 Monoclonal Antibody to Acetylserotonin-O-Methyltransferase (ASMT) WB; IHC; ICC; IP.
Assay Kits SED496Hu ELISA Kit for Acetylserotonin-O-Methyltransferase (ASMT) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Acetylserotonin-O-Methyltransferase (ASMT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Acetylserotonin-O-Methyltransferase (ASMT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Acetylserotonin-O-Methyltransferase (ASMT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Acetylserotonin-O-Methyltransferase (ASMT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Acetylserotonin-O-Methyltransferase (ASMT) ELISA Kit Customized Service Offer
  1. "Structural analysis of the human hydroxyindole-O-methyltransferase gene. Presence of two distinct promoters."J. Biol. Chem. 269:31969-31977(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Human hydroxyindole-O-methyltransferase: presence of LINE-1 fragment in a cDNA clone and pineal mRNA."DNA Cell Biol. 12:715-727(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Human hydroxyindole-O-methyltransferase in pineal gland, retina and Y79 retinoblastoma cells."Brain Res. 696:37-48(1995) [PubMed] [Europe PMC] [Abstract]
  7. "Hydroxyindole-O-methyltransferase in Y-79 cells: regulation by serum."Brain Res. 727:118-124(1996) [PubMed] [Europe PMC] [Abstract]
  8. "Retinoic acid increases hydroxyindole-O-methyltransferase activity and mRNA in human Y-79 retinoblastoma cells."J. Neurochem. 67:1032-1038(1996) [PubMed] [Europe PMC] [Abstract]
  9. "Crystal structure and functional mapping of human ASMT, the last enzyme of the melatonin synthesis pathway."J. Pineal Res. 54:46-57(2013) [PubMed] [Europe PMC] [Abstract]
  10. "Is ASMT a susceptibility gene for autism spectrum disorders? A replication study in European populations."Mol. Psychiatry 12:977-979(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Abnormal melatonin synthesis in autism spectrum disorders." Mol. Psychiatry 13:90-98(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Mutation screening of ASMT, the last enzyme of the melatonin pathway, in a large sample of patients with intellectual disability." BMC Med. Genet. 12:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Genetic variations of the melatonin pathway in patients with attention-deficit and hyperactivity disorders." J. Pineal Res. 51:394-399(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Genetic and functional abnormalities of the melatonin biosynthesis pathway in patients with bipolar disorder."Hum. Mol. Genet. 21:4030-4037(2012) [PubMed] [Europe PMC] [Abstract]
  15. "Sequencing ASMT identifies rare mutations in Chinese Han patients with autism."PLoS ONE 8:E53727-E53727(2013) [PubMed] [Europe PMC] [Abstract]