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5-Hydroxytryptamine Receptor 7 (HTR7)

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5-HT7; 5-HT-X; 5-HT7 Receptor; 5-HT7 Serotonin Receptor; 5-Hydroxytryptamine(Serotonin)Receptor 7(Adenylate Cyclase-Coupled)

5-Hydroxytryptamine Receptor 7 (HTR7)
CCC D497
HGNC 5302
MGI 99841
PubMed 10490701
RGD 71034
UniProt P34969
The receptor is a member of the GPCR superfamily of cell surface receptors and is activated by the neurotransmitter serotonin (5-HT) The 5-HT7 receptor is coupled to Gs (stimulates the production of the intracellular signaling molecule cAMP) and is expressed in a variety of human tissues, particularly in the brain, the gastrointestinal tract, and in various blood vessels. This receptor has been a drug development target for the treatment of several clinical disorders. The 5-HT7 receptor is encoded by the intron containing HTR7 gene, which in humans is transcribed into 3 different splice variants.In humans, the neurotransmitter serotonin (5-HT) plays an important role in various cognitive and behavioral functions. The serotonin receptor encoded by the HTR7 gene belongs to the superfamily of G protein-coupled receptors (GPCRs).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 5-Hydroxytryptamine Receptor 7 (HTR7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 5-Hydroxytryptamine Receptor 7 (HTR7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 5-Hydroxytryptamine Receptor 7 (HTR7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 5-Hydroxytryptamine Receptor 7 (HTR7) CLIA Kit Customized Service Offer
n/a ELISA Kit for 5-Hydroxytryptamine Receptor 7 (HTR7) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 5-Hydroxytryptamine Receptor 7 (HTR7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 5-Hydroxytryptamine Receptor 7 (HTR7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 5-Hydroxytryptamine Receptor 7 (HTR7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 5-Hydroxytryptamine Receptor 7 (HTR7) CLIA Kit Customized Service Offer
n/a ELISA Kit for 5-Hydroxytryptamine Receptor 7 (HTR7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 5-Hydroxytryptamine Receptor 7 (HTR7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 5-Hydroxytryptamine Receptor 7 (HTR7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 5-Hydroxytryptamine Receptor 7 (HTR7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 5-Hydroxytryptamine Receptor 7 (HTR7) CLIA Kit Customized Service Offer
n/a ELISA Kit for 5-Hydroxytryptamine Receptor 7 (HTR7) ELISA Kit Customized Service Offer
  1. "Four 5-hydroxytryptamine7 (5-HT7) receptor isoforms in human and rat produced by alternative splicing: species differences due to altered intron-exon organization."J. Neurochem. 68:1372-1381(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase."J. Biol. Chem. 268:23422-23426(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome." Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Biochemical and pharmacological study of N-linked glycosylation of the human serotonin 5-HT(7)a receptor."FEBS J. 279:1994-2003(2012) [PubMed] [Europe PMC] [Abstract]
  8. "The human serotonin 7 (5-HT7) receptor gene: genomic organization and systematic mutation screening in schizophrenia and bipolar affective disorder."Mol. Psychiatry 1:392-397(1996) [PubMed] [Europe PMC] [Abstract]