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Heat Shock 70kDa Protein 14 (HSPA14)

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HSP-A14; HSP70-4; HSP70L1; HSP70-like protein 1; Heat shock protein HSP60

Heat Shock 70kDa Protein 14 (HSPA14)
CCC D503
HGNC 29526
MGI 1354164
PubMed 21208456
RGD 1303296
UniProt Q0VDF9
Wiki HSPA14
HSP70L1 expression was upregulated by heat stress, TNF-alpha, and phorbol esters. HSP70L1 interacted with human dendritic cells (DCs), resulting in DC maturation and activation. Although HSP70L1 shared common cell surface receptors with HSP70 (HSPA1A), including TLR2 and TLR4, there were functional differences between the 2 proteins. HSP70L1 and HSP70 stimulated DC secretion of the proinflammatory cytokines IL1B and TNF-alpha at comparable levels, but HSP70L1 was a more potent stimulator of IL12p70. HSP70L1 induced secretion of the chemokines MIP1A (CCL3), MIP1B (CCL4), and RANTES (CCL5) and expression of the chemokine receptors CCR7 and CXCR4 more potently than HSP70. In addition, HSP70L1, but not HSP70, could induce IP10 (CXCL10) secretion.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD503Hu01 Recombinant Heat Shock 70kDa Protein 14 (HSPA14) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD503Hu01 Polyclonal Antibody to Heat Shock 70kDa Protein 14 (HSPA14) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Heat Shock 70kDa Protein 14 (HSPA14) CLIA Kit Customized Service Offer
n/a ELISA Kit for Heat Shock 70kDa Protein 14 (HSPA14) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Heat Shock 70kDa Protein 14 (HSPA14) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Heat Shock 70kDa Protein 14 (HSPA14) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Heat Shock 70kDa Protein 14 (HSPA14) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Heat Shock 70kDa Protein 14 (HSPA14) CLIA Kit Customized Service Offer
n/a ELISA Kit for Heat Shock 70kDa Protein 14 (HSPA14) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Heat Shock 70kDa Protein 14 (HSPA14) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Heat Shock 70kDa Protein 14 (HSPA14) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Heat Shock 70kDa Protein 14 (HSPA14) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Heat Shock 70kDa Protein 14 (HSPA14) CLIA Kit Customized Service Offer
n/a ELISA Kit for Heat Shock 70kDa Protein 14 (HSPA14) ELISA Kit Customized Service Offer
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  2. "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Hsp70-like protein 1 fusion protein enhances induction of carcinoembryonic antigen-specific CD8+ CTL response by dendritic cell vaccine."Cancer Res. 65:4947-4954(2005) [PubMed] [Europe PMC] [Abstract]
  7. "The chaperones MPP11 and Hsp70L1 form the mammalian ribosome-associated complex."Proc. Natl. Acad. Sci. U.S.A. 102:10064-10069(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Human Mpp11 J protein: ribosome-tethered molecular chaperones are ubiquitous."Science 308:1032-1034(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Protective effect of a RSV subunit vaccine candidate G1F/M2 was enhanced by a HSP70-Like protein in mice."Biochem. Biophys. Res. Commun. 377:495-499(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  13. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]