Heat Shock Protein 75kDa, Mitochondrial (HSP75)

HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. TRAP1 is a mitochondrial HSP90 protein. Other HSP90 proteins are found in cytosol (HSP90AA1) and endoplasmic reticulum (HSP90B1) (Chen et al., 2005). The deduced 661-amino acid protein is 60% similar to HSP90 family members, although it lacks the highly charged domain found in HSP90 proteins. Northern blot analysis revealed variable but ubiquitous expression of a 2.7-kb TRAP1 transcript.