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Amyloid Beta Precursor Protein Binding Protein A1 (APBA1)

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APB-A1; MINT1; X11; X11A; X11ALPHA; Adapter protein X11alpha; Neuron-specific X11 protein; Neuronal Munc18-1-interacting protein 1

Amyloid Beta Precursor Protein Binding Protein A1 (APBA1)
CCC D526
HGNC 578
MGI 1860297
PubMed 22136355
RGD 620844
UniProt Q02410
Wiki APBA1
APBA1 is a member of the X11 protein family. It is a neuronal adaptor protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilises APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. The deduced 837-amino acid MINT1 protein contains an N-terminal domain that binds to Munc18-1, a middle phosphotyrosine-binding (PTB) domain that binds to phosphatidylinositol phosphates, and 2 C-terminal PDZ domains.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Amyloid Beta Precursor Protein Binding Protein A1 (APBA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Amyloid Beta Precursor Protein Binding Protein A1 (APBA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Amyloid Beta Precursor Protein Binding Protein A1 (APBA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Amyloid Beta Precursor Protein Binding Protein A1 (APBA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Amyloid Beta Precursor Protein Binding Protein A1 (APBA1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Amyloid Beta Precursor Protein Binding Protein A1 (APBA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Amyloid Beta Precursor Protein Binding Protein A1 (APBA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Amyloid Beta Precursor Protein Binding Protein A1 (APBA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Amyloid Beta Precursor Protein Binding Protein A1 (APBA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Amyloid Beta Precursor Protein Binding Protein A1 (APBA1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Amyloid Beta Precursor Protein Binding Protein A1 (APBA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Amyloid Beta Precursor Protein Binding Protein A1 (APBA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Amyloid Beta Precursor Protein Binding Protein A1 (APBA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Amyloid Beta Precursor Protein Binding Protein A1 (APBA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Amyloid Beta Precursor Protein Binding Protein A1 (APBA1) ELISA Kit Customized Service Offer
  1. "Mints, Munc18-interacting proteins in synaptic vesicle exocytosis."J. Biol. Chem. 272:31459-31464(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion."J. Biol. Chem. 273:14761-14766(1998) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Gene in the region of the Friedreich ataxia locus encodes a putative transmembrane protein expressed in the nervous system."Proc. Natl. Acad. Sci. U.S.A. 90:109-113(1993) [PubMed] [Europe PMC] [Abstract]
  5. "The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein."Mol. Cell. Biol. 16:6229-6241(1996) [PubMed] [Europe PMC] [Abstract]
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  7. "An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter."NeuroReport 21:761-766(2010) [PubMed] [Europe PMC] [Abstract]
  8. "A new Mint1 isoform, but not the conventional Mint1, interacts with the small GTPase Rab6."PLoS ONE 8:E64149-E64149(2013) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain."EMBO J. 16:6141-6150(1997) [PubMed] [Europe PMC] [Abstract]
  11. "Solution structure of the first PDZ domain of amyloid beta A4 precursor protein-binding family A, member 1."Submitted (NOV-2005) to the PDB data bank