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Prostaglandin Reductase 1 (PTGR1)

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LTB4DH; ZADH3; NADP-dependent leukotriene B4 12-hydroxydehydrogenase; Zinc Binding Alcohol Dehydrogenase Domain Containing 3; 15-oxoprostaglandin 13-reductase

Prostaglandin Reductase 1 (PTGR1)
CCC D530
HGNC 18429
MGI 1914353
PubMed 22895897
RGD 621195
UniProt Q14914
PTGR1 isan enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants.
Leukotriene B(4) 12-hydroxydehydrogenase catalyzes the conversion of leukotriene B(4) into 12-oxo-leukotriene B(4), its less-active metabolite.The identity between the porcine and human sequences they obtained is 83.5% at the amino acid level and 84.7% at the nucleotide level. Both enzymes are highly homologous with a protein, AdRab-F, expressed only in adult rabbit small intestine

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Prostaglandin Reductase 1 (PTGR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Prostaglandin Reductase 1 (PTGR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Prostaglandin Reductase 1 (PTGR1) Polyclonal Antibody Customized Service Offer
Assay Kits SED530Hu ELISA Kit for Prostaglandin Reductase 1 (PTGR1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Prostaglandin Reductase 1 (PTGR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Prostaglandin Reductase 1 (PTGR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Prostaglandin Reductase 1 (PTGR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Prostaglandin Reductase 1 (PTGR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prostaglandin Reductase 1 (PTGR1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Prostaglandin Reductase 1 (PTGR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Prostaglandin Reductase 1 (PTGR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Prostaglandin Reductase 1 (PTGR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Prostaglandin Reductase 1 (PTGR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prostaglandin Reductase 1 (PTGR1) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "cDNA cloning, expression, and mutagenesis study of leukotriene B4 12-hydroxydehydrogenase."J. Biol. Chem. 271:2844-2850(1996) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  7. "Crystal structure of human NADP-dependent leukotriene B4 12-hydroxydehydrogenase."Submitted (MAY-2005) to the PDB data bank
  8. "Crystal structure of human leukotriene B4 12-hydroxydehydrogenase in complex with NADP and raloxifene."Submitted (JAN-2011) to the PDB data bank