Cytochrome P450 26B1 (CYP26B1)
[Edit]CYP26A2; P450RAI-2; Cytochrome P450 Family 26 Subfamily B Polypeptide 1; Cytochrome P450 retinoic acid-inactivating 2; Retinoic acid-metabolizing cytochrome
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Cytochrome P450 26B1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and the synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene is involved in the specific inactivation of all-trans-retinoic acid to hydroxylated forms, such as 4-oxo-, 4-OH-, and 18-OH-all-trans-retinoic acid.
Plays a key role in retinoic acid metabolism. Involved in the specific inactivation of all-trans-retinoic acid (RA). Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA.Highly expressed in brain, particularly in the cerebellum and pons.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPD541Hu01 | Recombinant Cytochrome P450 26B1 (CYP26B1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAD541Hu01 | Polyclonal Antibody to Cytochrome P450 26B1 (CYP26B1) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Cytochrome P450 26B1 (CYP26B1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Cytochrome P450 26B1 (CYP26B1) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Cytochrome P450 26B1 (CYP26B1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Cytochrome P450 26B1 (CYP26B1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Cytochrome P450 26B1 (CYP26B1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | SED541Mu | ELISA Kit for Cytochrome P450 26B1 (CYP26B1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Cytochrome P450 26B1 (CYP26B1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Cytochrome P450 26B1 (CYP26B1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Cytochrome P450 26B1 (CYP26B1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Cytochrome P450 26B1 (CYP26B1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Cytochrome P450 26B1 (CYP26B1) | ELISA Kit Customized Service Offer |
- "Identification of the human cytochrome P450, P450RAI-2, which is predominantly expressed in the adult cerebellum and is responsible for all-trans-retinoic acid metabolism."Proc. Natl. Acad. Sci. U.S.A. 97:6403-6408(2000) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Craniosynostosis and multiple skeletal anomalies in humans and zebrafish result from a defect in the localized degradation of retinoic acid."Am. J. Hum. Genet. 89:595-606(2011) [PubMed] [Europe PMC] [Abstract]