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Cytochrome P450 11B1 (CYP11B1)

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CPN1; CYP11B; FHI; CYPXIB1; S11BH; 11-Beta-Hydroxylase; Cytochrome P450 Family 11 Subfamily B Polypeptide 1; Steroid 11-beta-hydroxylase; Cytochrome P-450c11

Cytochrome P450 11B1 (CYP11B1)
CCC D546
HGNC 2591
MGI 88584
PubMed 9302260
RGD 2453
UniProt P15538
Wiki CYP11B1
Steroid 11β-hydroxylase is a steroid hydroxylase found in the zona fasciculata. Named officially the cytochrome P450 11B1, mitochondrial, it is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.
This protein localizes to the mitochondrial inner membrane and is involved in the conversion of 11-deoxycortisol to cortisol in the adrenal cortex. Mutations in this gene cause congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. Transcript variants encoding different isoforms have been noted for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome P450 11B1 (CYP11B1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome P450 11B1 (CYP11B1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome P450 11B1 (CYP11B1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytochrome P450 11B1 (CYP11B1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytochrome P450 11B1 (CYP11B1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD546Mu01 Recombinant Cytochrome P450 11B1 (CYP11B1) Positive Control; Immunogen; SDS-PAGE; WB.
RPD546Mu02 Recombinant Cytochrome P450 11B1 (CYP11B1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD546Mu01 Polyclonal Antibody to Cytochrome P450 11B1 (CYP11B1) WB; IHC; ICC; IP.
PAD546Mu02 Polyclonal Antibody to Cytochrome P450 11B1 (CYP11B1) WB; IHC; ICC; IP.
Assay Kits SED546Mu ELISA Kit for Cytochrome P450 11B1 (CYP11B1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD546Ra01 Recombinant Cytochrome P450 11B1 (CYP11B1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD546Ra01 Polyclonal Antibody to Cytochrome P450 11B1 (CYP11B1) WB; IHC; ICC; IP.
MAD546Ra21 Monoclonal Antibody to Cytochrome P450 11B1 (CYP11B1) WB; IHC; ICC; IP.
Assay Kits SED546Ra ELISA Kit for Cytochrome P450 11B1 (CYP11B1) Enzyme-linked immunosorbent assay for Antigen Detection.
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  9. "CYP11B1 mutations causing non-classic adrenal hyperplasia due to 11 beta-hydroxylase deficiency."Hum. Mol. Genet. 6:1829-1834(1997) [PubMed] [Europe PMC] [Abstract]
  10. "The C494F variant in the CYP11B1 gene is a sequence polymorphism in the Spanish population."J. Clin. Endocrinol. Metab. 84:4749-4749(1999) [PubMed] [Europe PMC] [Abstract]
  11. "Characterization of single-nucleotide polymorphisms in coding regions of human genes."Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
  12. ErratumNat. Genet. 23:373-373(1999)
  13. "Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."Nat. Genet. 22:239-247(1999) [PubMed] [Europe PMC] [Abstract]
  14. "21-Hydroxylase and 11beta-hydroxylase mutations in Romanian patients with classic congenital adrenal hyperplasia."J. Clin. Endocrinol. Metab. 90:5769-5773(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Only two mutations detected in 15 Tunisian patients with 11beta-hydroxylase deficiency: the p.Q356X and the novel p.G379V."Clin. Genet. 78:398-401(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Novel homozygous p.R454C mutation in the CYP11B1 gene leads to 11beta-hydroxylase deficiency in a Chinese patient."Fertil. Steril. 95:1122-1122(2011) [PubMed] [Europe PMC] [Abstract]