≡

Cytochrome P450 5A1 (CYP5A1)

[Edit]

TBXAS1; TS; CYP5; THAS; TXAS; TXS; Thromboxane A Synthase 1(Platelet); Cytochrome P450 Family 5 Subfamily A Polypeptide 1

Cytochrome P450 5A1 (CYP5A1)
CCC D549
HGNC 11609
MGI 98497
PubMed 11465543
RGD 3826
UniProt P24557
Wiki CYP5A1
CYP5A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity.
This endoplasmic reticulum membrane protein catalyzes the conversion of prostaglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. The gene expresses two transcript variants.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD549Hu01 Recombinant Cytochrome P450 5A1 (CYP5A1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD549Hu01 Polyclonal Antibody to Cytochrome P450 5A1 (CYP5A1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cytochrome P450 5A1 (CYP5A1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytochrome P450 5A1 (CYP5A1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome P450 5A1 (CYP5A1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome P450 5A1 (CYP5A1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome P450 5A1 (CYP5A1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytochrome P450 5A1 (CYP5A1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytochrome P450 5A1 (CYP5A1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome P450 5A1 (CYP5A1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome P450 5A1 (CYP5A1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome P450 5A1 (CYP5A1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytochrome P450 5A1 (CYP5A1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytochrome P450 5A1 (CYP5A1) ELISA Kit Customized Service Offer
  1. "Molecular cloning of human platelet thromboxane A synthase."Biochem. Biophys. Res. Commun. 178:1479-1484(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Primary structure of human thromboxane synthase determined from the cDNA sequence."J. Biol. Chem. 267:789-793(1992) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization of the human gene (TBXAS1) encoding thromboxane synthase."Eur. J. Biochem. 224:273-279(1994) [PubMed] [Europe PMC] [Abstract]
  4. "Identification of genetic variants in the human thromboxane synthase gene (CYP5A1)."Mutat. Res. 432:61-67(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Isolation of partial complementary DNA encoding human thromboxane synthase."Biochem. Biophys. Res. Commun. 177:286-291(1991) [PubMed] [Europe PMC] [Abstract]
  9. "Immunoaffinity purification of human thromboxane synthase."Arch. Biochem. Biophys. 280:325-330(1990) [PubMed] [Europe PMC] [Abstract]
  10. Thesis (1990), University of Konstanz, Germany
  11. "Amino-terminal topology of thromboxane synthase in the endoplasmic reticulum."J. Biol. Chem. 268:19483-19490(1993) [PubMed] [Europe PMC] [Abstract]
  12. "Severe bleeding associated with defective thromboxane synthetase."Lancet 1:157-157(1980) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Characterization of single-nucleotide polymorphisms in coding regions of human genes."Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
  15. ErratumNat. Genet. 23:373-373(1999)
  16. "Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."Nat. Genet. 22:239-247(1999) [PubMed] [Europe PMC] [Abstract]
  17. "Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population."J. Hum. Genet. 48:249-270(2003) [PubMed] [Europe PMC] [Abstract]
  18. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  19. "Thromboxane synthase mutations in an increased bone density disorder (Ghosal syndrome)."Nat. Genet. 40:284-286(2008) [PubMed] [Europe PMC] [Abstract]