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Mitogen Activated Protein Kinase Kinase Kinase Kinase 1 (MAP4K1)

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HPK1; MEKKK 1; Hematopoietic Progenitor Kinase 1; MAPK/ERK kinase kinase kinase 1

Mitogen Activated Protein Kinase Kinase Kinase Kinase 1 (MAP4K1)
CCC D551
HGNC 6863
MGI 1346882
PubMed 22801218
RGD 1305463
UniProt Q92918
Wiki MAP4K1
Using a subtractive hybridization between a mouse cDNA granulocyte-macrophage progenitor and an erythrocyte megakaryocyte progenitor, Hu et al. (1996) identified a human hematopoietic serine/threonine protein kinase that they called hematopoietic progenitor kinase-1, or HPK1.
The authors detected 2 major distinct HPK1 transcripts (2.8 kb and 6.0 kb) primarily in hematopoietic organs, such as bone marrow and fetal liver. HPK1 encodes an 833-amino acid polypeptide with a predicted molecular weight of 90 kD and an actual weight of 97 kD. HPK1 is distantly related to the p21/Cdc42/Rac1-activated kinase (PAK) and yeast STE20 implicated in the mitogen-activated protein kinase (MAPK) cascade.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitogen Activated Protein Kinase Kinase Kinase Kinase 1 (MAP4K1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase Kinase 1 (MAP4K1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase Kinase 1 (MAP4K1) Polyclonal Antibody Customized Service Offer
Assay Kits SED551Hu ELISA Kit for Mitogen Activated Protein Kinase Kinase Kinase Kinase 1 (MAP4K1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitogen Activated Protein Kinase Kinase Kinase Kinase 1 (MAP4K1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase Kinase 1 (MAP4K1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase Kinase 1 (MAP4K1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase Kinase Kinase Kinase 1 (MAP4K1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase Kinase Kinase Kinase 1 (MAP4K1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitogen Activated Protein Kinase Kinase Kinase Kinase 1 (MAP4K1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase Kinase 1 (MAP4K1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase Kinase 1 (MAP4K1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase Kinase Kinase Kinase 1 (MAP4K1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase Kinase Kinase Kinase 1 (MAP4K1) ELISA Kit Customized Service Offer
  1. "Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade."Genes Dev. 10:2251-2264(1996) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  4. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
  7. "The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1."J. Biol. Chem. 289:4009-4017(2014) [PubMed] [Europe PMC] [Abstract]