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Mitogen Activated Protein Kinase Kinase 7 (MAP2K7)

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Jnkk2; MAPKK7; MKK7; PRKMK7; SKK4; JNK-activating kinase 2; Stress-activated protein kinase kinase 4; c-Jun N-terminal kinase kinase 2

Mitogen Activated Protein Kinase Kinase 7 (MAP2K7)
CCC D560
HGNC 6847
MGI 1346871
PubMed 22899651
RGD 1560043
UniProt O14733
Wiki MAP2K7
MAP2K7 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK.
This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined.Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD560Hu01 Recombinant Mitogen Activated Protein Kinase Kinase 7 (MAP2K7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD560Hu01 Polyclonal Antibody to Mitogen Activated Protein Kinase Kinase 7 (MAP2K7) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase Kinase 7 (MAP2K7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase Kinase 7 (MAP2K7) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD560Mu01 Recombinant Mitogen Activated Protein Kinase Kinase 7 (MAP2K7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD560Mu01 Polyclonal Antibody to Mitogen Activated Protein Kinase Kinase 7 (MAP2K7) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase Kinase 7 (MAP2K7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase Kinase 7 (MAP2K7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitogen Activated Protein Kinase Kinase 7 (MAP2K7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitogen Activated Protein Kinase Kinase 7 (MAP2K7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitogen Activated Protein Kinase Kinase 7 (MAP2K7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase Kinase 7 (MAP2K7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase Kinase 7 (MAP2K7) ELISA Kit Customized Service Offer
  1. "Molecular cloning and characterization of human JNKK2, a novel jun NH2-terminal kinase-specific kinase."Mol. Cell. Biol. 17:7407-7416(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of c-Jun NH2-terminal protein kinase (JNK)-activating kinase 2 as an activator of JNK but not p38."J. Biol. Chem. 272:24751-24754(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli."J. Biol. Chem. 273:9344-9351(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Cloning and expression of human mitogen-activated protein kinase kinase 7gamma1."Biochem. Biophys. Res. Commun. 341:679-683(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase."Proc. Natl. Acad. Sci. U.S.A. 94:7337-7342(1997) [PubMed] [Europe PMC] [Abstract]
  8. "The JIP group of mitogen-activated protein kinase scaffold proteins."Mol. Cell. Biol. 19:7245-7254(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor."Biochem. J. 352:739-745(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade."J. Biol. Chem. 277:40703-40709(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases."Mol. Cell 18:295-306(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein."PLoS ONE 3:E1660-E1660(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Differential regulation and properties of MAPKs."Oncogene 26:3100-3112(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Diverse physiological functions of MKK4 and MKK7 during early embryogenesis."J. Biochem. 148:393-401(2010) [PubMed] [Europe PMC] [Abstract]
  16. "RASSF7 negatively regulates pro-apoptotic JNK signaling by inhibiting the activity of phosphorylated-MKK7."Cell Death Differ. 18:645-655(2011) [PubMed] [Europe PMC] [Abstract]
  17. "The bottleneck of JNK signaling: molecular and functional characteristics of MKK4 and MKK7."Eur. J. Cell Biol. 90:536-544(2011) [PubMed] [Europe PMC] [Abstract]
  18. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  19. "Crystal structure of human mitogen-activated protein kinase kinase 7 activated mutant (s287d, t291d)."Submitted (FEB-2009) to the PDB data bank
  20. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]