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Mitogen Activated Protein Kinase Kinase 4 (MAP2K4)

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JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4; SEK1; SERK1; SKK1; c-Jun N-terminal kinase kinase 1; JNK-activating kinase 1; Stress-activated protein kinase kinase 1

Mitogen Activated Protein Kinase Kinase 4 (MAP2K4)
CCC D564
HGNC 6844
MGI 1346869
PubMed 11754110
RGD 1307040
UniProt P45985
Wiki MAP2K4
Dual specificity mitogen-activated protein kinase kinase 4 is a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK1.
This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD564Hu01 Recombinant Mitogen Activated Protein Kinase Kinase 4 (MAP2K4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD564Hu01 Polyclonal Antibody to Mitogen Activated Protein Kinase Kinase 4 (MAP2K4) WB; ICC; IHC-P; IHC-F; ELISA.
LAD564Hu71 Biotin-Linked Polyclonal Antibody to Mitogen Activated Protein Kinase Kinase 4 (MAP2K4) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase Kinase 4 (MAP2K4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase Kinase 4 (MAP2K4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitogen Activated Protein Kinase Kinase 4 (MAP2K4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitogen Activated Protein Kinase Kinase 4 (MAP2K4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitogen Activated Protein Kinase Kinase 4 (MAP2K4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase Kinase 4 (MAP2K4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase Kinase 4 (MAP2K4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitogen Activated Protein Kinase Kinase 4 (MAP2K4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitogen Activated Protein Kinase Kinase 4 (MAP2K4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitogen Activated Protein Kinase Kinase 4 (MAP2K4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase Kinase 4 (MAP2K4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase Kinase 4 (MAP2K4) ELISA Kit Customized Service Offer
  1. "Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms."Science 267:682-685(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2."Science 268:286-290(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene."Cancer Res. 58:2339-2342(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6."EMBO J. 15:7026-7035(1996) [PubMed] [Europe PMC] [Abstract]
  8. "Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor."Biochem. J. 352:739-745(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3."Science 290:1574-1577(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade."J. Biol. Chem. 277:40703-40709(2002) [PubMed] [Europe PMC] [Abstract]
  11. "A docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substrates."J. Biol. Chem. 278:32662-32672(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases."Mol. Cell 18:295-306(2005) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  15. "A scanning peptide array approach uncovers association sites within the JNK/beta arrestin signalling complex."FEBS Lett. 583:3310-3316(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Differential regulation and properties of MAPKs."Oncogene 26:3100-3112(2007) [PubMed] [Europe PMC] [Abstract]
  17. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Diverse physiological functions of MKK4 and MKK7 during early embryogenesis."J. Biochem. 148:393-401(2010) [PubMed] [Europe PMC] [Abstract]
  19. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  20. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  21. "The bottleneck of JNK signaling: molecular and functional characteristics of MKK4 and MKK7."Eur. J. Cell Biol. 90:536-544(2011) [PubMed] [Europe PMC] [Abstract]
  22. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  23. "Crystal structures of MKK4 kinase domain reveal that substrate peptide binds to an allosteric site and induces an auto-inhibition state."Biochem. Biophys. Res. Commun. 400:369-373(2010) [PubMed] [Europe PMC] [Abstract]
  24. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]