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Mitogen Activated Protein Kinase Kinase Kinase 8 (MAP3K8)

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COT; EST; ESTF; TPL2; Tpl-2; c-COT; Cancer Osaka thyroid oncogene; Proto-oncogene c-Cot; Serine/threonine-protein kinase cot; Tumor progression locus 2

Mitogen Activated Protein Kinase Kinase Kinase 8 (MAP3K8)
CCC D568
HGNC 6860
MGI 1346878
PubMed 15287022
RGD 620969
UniProt P41279
Wiki MAP3K8
Mitogen-activated protein kinase kinase kinase 8 is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB.
This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1,p105 (NFKB1). This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitogen Activated Protein Kinase Kinase Kinase 8 (MAP3K8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase 8 (MAP3K8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase 8 (MAP3K8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase Kinase Kinase 8 (MAP3K8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase Kinase Kinase 8 (MAP3K8) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitogen Activated Protein Kinase Kinase Kinase 8 (MAP3K8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase 8 (MAP3K8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase 8 (MAP3K8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase Kinase Kinase 8 (MAP3K8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase Kinase Kinase 8 (MAP3K8) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitogen Activated Protein Kinase Kinase Kinase 8 (MAP3K8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase 8 (MAP3K8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase 8 (MAP3K8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase Kinase Kinase 8 (MAP3K8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase Kinase Kinase 8 (MAP3K8) ELISA Kit Customized Service Offer
  1. "Structure and transforming potential of the human cot oncogene encoding a putative protein kinase."Mol. Cell. Biol. 11:4088-4096(1991) [PubMed] [Europe PMC] [Abstract]
  2. "The human cot proto-oncogene encodes two protein serine/threonine kinases with different transforming activities by alternative initiation of translation."J. Biol. Chem. 268:22723-22732(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Expression cDNA cloning of a serine kinase transforming gene."Oncogene 8:1329-1333(1993) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "COT kinase proto-oncogene expression in T cells: implication of the JNK/SAPK signal transduction pathway in COT promoter activation."J. Biol. Chem. 275:31379-31386(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Identification and characterization of protein products of the cot oncogene with serine kinase activity."Oncogene 6:1515-1519(1991) [PubMed] [Europe PMC] [Abstract]
  9. "TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105."Nature 397:363-368(1999) [PubMed] [Europe PMC] [Abstract]
  10. "p27kip protein levels and E2F activity are targets of Cot kinase during G1 phase progression in T cells."J. Immunol. 166:6084-6090(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling."J. Biol. Chem. 278:47089-47097(2003) [PubMed] [Europe PMC] [Abstract]
  12. "NF-kappaB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase."Mol. Cell 11:685-694(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Phosphorylation of threonine 290 in the activation loop of Tpl2/Cot is necessary but not sufficient for kinase activity."J. Biol. Chem. 279:52117-52123(2004) [PubMed] [Europe PMC] [Abstract]
  14. "ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability."Mol. Cell. Biol. 24:5235-5248(2004) [PubMed] [Europe PMC] [Abstract]
  15. "Phosphorylation at Thr-290 regulates Tpl2 binding to NF-kappaB1/p105 and Tpl2 activation and degradation by lipopolysaccharide."Proc. Natl. Acad. Sci. U.S.A. 102:2350-2355(2005) [PubMed] [Europe PMC] [Abstract]
  16. "TRAF6 and Src kinase activity regulates Cot activation by IL-1."Cell. Signal. 18:1376-1385(2006) [PubMed] [Europe PMC] [Abstract]
  17. "Characterization of phosphorylation sites on Tpl2 using IMAC enrichment and a linear ion trap mass spectrometer."J. Proteome Res. 6:2269-2276(2007) [PubMed] [Europe PMC] [Abstract]
  18. "Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii."J. Exp. Med. 205:2803-2812(2008) [PubMed] [Europe PMC] [Abstract]
  19. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  20. "IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2."Biochem. J. 424:109-118(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis."Diabetes 59:61-70(2010) [PubMed] [Europe PMC] [Abstract]
  22. "IkappaB kinase 2 regulates TPL-2 activation of extracellular signal-regulated kinases 1 and 2 by direct phosphorylation of TPL-2 serine 400."Mol. Cell. Biol. 32:4684-4690(2012) [PubMed] [Europe PMC] [Abstract]
  23. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]