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Mitogen Activated Protein Kinase 13 (MAPK13)

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SAPK4; p38 Delta; Mitogen-activated protein kinase p38 delta; Stress-activated protein kinase 4

Mitogen Activated Protein Kinase 13 (MAPK13)
CCC D578
HGNC 6875
MGI 1346864
PubMed 19816939
RGD 3045
UniProt O15264
Wiki MAPK13
Mitogen Activated Protein Kinase 13 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development.
This kinase is closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and cellular stress. MAP kinase kinases 3, and 6 can phosphorylate and activate this kinase. Transcription factor ATF2, and microtubule dynamics regulator stathmin have been shown to be the substrates of this kinase.Expressed in testes, pancreas, small intestine, lung and kidney. Abundant in macrophages, also present in neutrophils, CD4+ T-cells, and endothelial cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD578Hu01 Recombinant Mitogen Activated Protein Kinase 13 (MAPK13) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD578Hu01 Polyclonal Antibody to Mitogen Activated Protein Kinase 13 (MAPK13) WB; ICC; IHC-P; IHC-F; ELISA.
MAD578Hu21 Monoclonal Antibody to Mitogen Activated Protein Kinase 13 (MAPK13) WB; IHC; ICC; IP.
Assay Kits SED578Hu ELISA Kit for Mitogen Activated Protein Kinase 13 (MAPK13) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitogen Activated Protein Kinase 13 (MAPK13) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitogen Activated Protein Kinase 13 (MAPK13) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitogen Activated Protein Kinase 13 (MAPK13) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase 13 (MAPK13) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase 13 (MAPK13) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitogen Activated Protein Kinase 13 (MAPK13) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitogen Activated Protein Kinase 13 (MAPK13) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitogen Activated Protein Kinase 13 (MAPK13) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase 13 (MAPK13) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase 13 (MAPK13) ELISA Kit Customized Service Offer
  1. "Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases."EMBO J. 16:3563-3571(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta."J. Biol. Chem. 272:30122-30128(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase."J. Biol. Chem. 272:23668-23674(1997) [PubMed] [Europe PMC] [Abstract]
  4. "Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles."Biochem. Biophys. Res. Commun. 235:533-538(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Murine p38-delta mitogen-activated protein kinase, a developmentally regulated protein kinase that is activated by stress and proinflammatory cytokines."J. Biol. Chem. 274:7095-7102(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Structure and polymorphism of two stress-activated protein kinase genes centromeric of the MHC: SAPK2a and SAPK4."DNA Seq. 10:229-243(1999) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of stathmin as a novel substrate for p38 delta."Biochem. Biophys. Res. Commun. 249:791-796(1998) [PubMed] [Europe PMC] [Abstract]
  10. "Differential expression and activation of p38 mitogen-activated protein kinase alpha, beta, gamma, and delta in inflammatory cell lineages."J. Immunol. 162:4246-4252(1999) [PubMed] [Europe PMC] [Abstract]
  11. "Fibroblast growth factor homologous factors are intracellular signaling proteins."Curr. Biol. 11:793-797(2001) [PubMed] [Europe PMC] [Abstract]
  12. "A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta."EMBO J. 20:4360-4369(2001) [PubMed] [Europe PMC] [Abstract]
  13. "Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases in intact cells."FEBS Lett. 515:151-154(2002) [PubMed] [Europe PMC] [Abstract]
  14. "Evidence that phosphorylation of the microtubule-associated protein Tau by SAPK4/p38delta at Thr50 promotes microtubule assembly."J. Cell Sci. 118:397-408(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Activation of PKCdelta and p38delta MAPK during okadaic acid dependent keratinocyte apoptosis."Arch. Dermatol. Res. 299:71-83(2007) [PubMed] [Europe PMC] [Abstract]
  16. "p38MAPK delta controls c-Myb degradation in response to stress."Blood Cells Mol. Dis. 40:388-394(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  18. "MKP-1 inhibits high NaCl-induced activation of p38 but does not inhibit the activation of TonEBP/OREBP: opposite roles of p38alpha and p38delta."Proc. Natl. Acad. Sci. U.S.A. 105:5620-5625(2008) [PubMed] [Europe PMC] [Abstract]
  19. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Human p38 delta MAP kinase mediates UV irradiation induced up-regulation of the gene expression of chemokine BRAK/CXCL14."Biochem. Biophys. Res. Commun. 396:1060-1064(2010) [PubMed] [Europe PMC] [Abstract]
  21. "p38delta mitogen-activated protein kinase regulates skin homeostasis and tumorigenesis."Cell Cycle 9:498-505(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Mechanisms and functions of p38 MAPK signalling."Biochem. J. 429:403-417(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  24. "Crystal structure of p38delta kinase."Submitted (JUN-2009) to the PDB data bank
  25. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]