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Mitogen Activated Protein Kinase Activated Protein Kinase 5 (MAPKAPK5)

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PRAK; p38-regulated/activated protein kinase

Mitogen Activated Protein Kinase Activated Protein Kinase 5 (MAPKAPK5)
CCC D580
HGNC 6889
MGI 1333110
PubMed 9480836
RGD 1564113
UniProt Q8IW41
Wiki MAPKAPK5
MAP kinase-activated protein kinase 5 is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported.MAPKAPK5 encodes a predicted 471-amino acid protein that shares 20 to 30% sequence identity with RSK, MNK, and MAPKAPK kinases. MAPKAPK5 contains the conserved protein kinase domains I through XI, which are characteristic of all protein kinases.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitogen Activated Protein Kinase Activated Protein Kinase 5 (MAPKAPK5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitogen Activated Protein Kinase Activated Protein Kinase 5 (MAPKAPK5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitogen Activated Protein Kinase Activated Protein Kinase 5 (MAPKAPK5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase Activated Protein Kinase 5 (MAPKAPK5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase Activated Protein Kinase 5 (MAPKAPK5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitogen Activated Protein Kinase Activated Protein Kinase 5 (MAPKAPK5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitogen Activated Protein Kinase Activated Protein Kinase 5 (MAPKAPK5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitogen Activated Protein Kinase Activated Protein Kinase 5 (MAPKAPK5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase Activated Protein Kinase 5 (MAPKAPK5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase Activated Protein Kinase 5 (MAPKAPK5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitogen Activated Protein Kinase Activated Protein Kinase 5 (MAPKAPK5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitogen Activated Protein Kinase Activated Protein Kinase 5 (MAPKAPK5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitogen Activated Protein Kinase Activated Protein Kinase 5 (MAPKAPK5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase Activated Protein Kinase 5 (MAPKAPK5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase Activated Protein Kinase 5 (MAPKAPK5) ELISA Kit Customized Service Offer
  1. "PRAK, a novel protein kinase regulated by the p38 MAP kinase."EMBO J. 17:3372-3384(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "p62 functions as a p38 MAP kinase regulator."Biochem. Biophys. Res. Commun. 269:521-525(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Regulation of PRAK subcellular location by p38 MAP kinases."Mol. Biol. Cell 14:2603-2616(2003) [PubMed] [Europe PMC] [Abstract]
  7. "14-3-3epsilon inhibits MK5-mediated cell migration by disrupting F-actin polymerization."Cell. Signal. 19:2379-2387(2007) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "PKA-induced F-actin rearrangement requires phosphorylation of Hsp27 by the MAPKAP kinase MK5."Cell. Signal. 21:712-718(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
  13. "PRAK is essential for ras-induced senescence and tumor suppression."Cell 128:295-308(2007) [PubMed] [Europe PMC] [Abstract]
  14. "The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis."Mol. Cell 41:445-457(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Mitogen-activated protein kinase p38 and MK2, MK3 and MK5: menage a trois or menage a quatre?"Cell. Signal. 22:1185-1192(2010) [PubMed] [Europe PMC] [Abstract]