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Protein Tyrosine Phosphatase, Non Receptor Type 11 (PTPN11)

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BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2; Noonan Syndrome 1; Protein-tyrosine phosphatase 1D; Protein-tyrosine phosphatase 2C

Protein Tyrosine Phosphatase, Non Receptor Type 11 (PTPN11)
CCC D584
HGNC 9644
MGI 99511
PubMed 11704759
RGD 3447
UniProt Q06124
Wiki PTPN11
PTPN11 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates.
This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Tyrosine Phosphatase, Non Receptor Type 11 (PTPN11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 11 (PTPN11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 11 (PTPN11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 11 (PTPN11) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 11 (PTPN11) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Tyrosine Phosphatase, Non Receptor Type 11 (PTPN11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 11 (PTPN11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 11 (PTPN11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 11 (PTPN11) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 11 (PTPN11) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD584Ra01 Recombinant Protein Tyrosine Phosphatase, Non Receptor Type 11 (PTPN11) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD584Ra01 Polyclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 11 (PTPN11) WB; IHC; ICC; IP.
MAD584Ra21 Monoclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 11 (PTPN11) WB; IHC; ICC; IP.
Assay Kits SED584Ra ELISA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 11 (PTPN11) Enzyme-linked immunosorbent assay for Antigen Detection.
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  44. "Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome."Nat. Genet. 29:465-468(2001) [PubMed] [Europe PMC] [Abstract]
  45. ErratumNat. Genet. 29:491-491(2001)
  46. ErratumNat. Genet. 30:123-123(2001)
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  48. "Grouping of multiple-lentigines/LEOPARD and Noonan syndromes on the PTPN11 gene."Am. J. Hum. Genet. 71:389-394(2002) [PubMed] [Europe PMC] [Abstract]
  49. "PTPN11 mutations in Noonan syndrome type I: detection of recurrent mutations in exons 3 and 13."Hum. Mutat. 20:298-304(2002) [PubMed] [Europe PMC] [Abstract]
  50. "PTPN11 (protein-tyrosine phosphatase, nonreceptor-type 11) mutations in seven Japanese patients with Noonan syndrome."J. Clin. Endocrinol. Metab. 87:3529-3533(2002) [PubMed] [Europe PMC] [Abstract]
  51. "PTPN11 mutation in a large family with Noonan syndrome and dizygous twinning."Eur. J. Hum. Genet. 11:85-88(2003) [PubMed] [Europe PMC] [Abstract]
  52. "Spectrum of mutations in PTPN11 and genotype-phenotype correlation in 96 patients with Noonan syndrome and five patients with cardio-facio-cutaneous syndrome."Eur. J. Hum. Genet. 11:201-206(2003) [PubMed] [Europe PMC] [Abstract]
  53. ErratumEur. J. Hum. Genet. 11:551-551(2003)
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  57. "Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia."Nat. Genet. 34:148-150(2003) [PubMed] [Europe PMC] [Abstract]
  58. "Clinical variability in a Noonan syndrome family with a new PTPN11 gene mutation."Am. J. Med. Genet. A 130:378-383(2004) [PubMed] [Europe PMC] [Abstract]
  59. "Two novel and one recurrent PTPN11 mutations in LEOPARD syndrome."Am. J. Med. Genet. A 130:432-434(2004) [PubMed] [Europe PMC] [Abstract]
  60. "PTPN11 mutations in patients with LEOPARD syndrome: a French multicentric experience."J. Med. Genet. 41:E117-E117(2004) [PubMed] [Europe PMC] [Abstract]
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  64. "Acute myelomonocytic leukemia in a boy with LEOPARD syndrome (PTPN11 gene mutation positive)."J. Pediatr. Hematol. Oncol. 28:123-125(2006) [PubMed] [Europe PMC] [Abstract]
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  66. "A PTPN11 allele encoding a catalytically impaired SHP2 protein in a patient with a Noonan syndrome phenotype."Am. J. Med. Genet. A 164:2351-2355(2014) [PubMed] [Europe PMC] [Abstract]