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Protein Tyrosine Phosphatase, Non Receptor Type 2 (PTPN2)

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PTPT; TC-PTP; TCELLPTP; TCPTP; T-cell protein-tyrosine phosphatase

Protein Tyrosine Phosphatase, Non Receptor Type 2 (PTPN2)
CCC D585
HGNC 9650
MGI 97806
PubMed 22377701
RGD 620710
UniProt P17706
Wiki PTPN2
Tyrosine-protein phosphatase non-receptor type 2 is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Three alternatively spliced variants of this gene, which encode isoforms differing at their extreme C-termini, have been described. The different C-termini are thought to determine the substrate specificity, as well as the cellular localization of the isoforms.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD585Hu01 Recombinant Protein Tyrosine Phosphatase, Non Receptor Type 2 (PTPN2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD585Hu01 Polyclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 2 (PTPN2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 2 (PTPN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 2 (PTPN2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD585Mu01 Recombinant Protein Tyrosine Phosphatase, Non Receptor Type 2 (PTPN2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD585Mu01 Polyclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 2 (PTPN2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 2 (PTPN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 2 (PTPN2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Tyrosine Phosphatase, Non Receptor Type 2 (PTPN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 2 (PTPN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 2 (PTPN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 2 (PTPN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 2 (PTPN2) ELISA Kit Customized Service Offer
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  8. "Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase."Mol. Cell. Biol. 18:1622-1634(1998) [PubMed] [Europe PMC] [Abstract]
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  17. "Negative regulation of EGFR signalling through integrin-alpha1beta1-mediated activation of protein tyrosine phosphatase TCPTP."Nat. Cell Biol. 7:78-85(2005) [PubMed] [Europe PMC] [Abstract]
  18. "Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase."Nat. Immunol. 6:253-260(2005) [PubMed] [Europe PMC] [Abstract]
  19. "The catalytic activity of the eukaryotic initiation factor-2alpha kinase PKR is required to negatively regulate Stat1 and Stat3 via activation of the T-cell protein-tyrosine phosphatase."J. Biol. Chem. 281:9439-9449(2006) [PubMed] [Europe PMC] [Abstract]
  20. "Evidence for a role of transmembrane protein p25 in localization of protein tyrosine phosphatase TC48 to the ER."J. Cell Sci. 119:1703-1714(2006) [PubMed] [Europe PMC] [Abstract]
  21. "T-cell protein tyrosine phosphatase, distinctively expressed in activated-B-cell-like diffuse large B-cell lymphomas, is the nuclear phosphatase of STAT6."Mol. Cell. Biol. 27:2166-2179(2007) [PubMed] [Europe PMC] [Abstract]
  22. "Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase."J. Biol. Chem. 283:34374-34383(2008) [PubMed] [Europe PMC] [Abstract]
  23. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  24. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  25. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
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  28. "Tyrosine phosphorylation of a SNARE protein, Syntaxin 17: Implications for membrane trafficking in the early secretory pathway."Biochim. Biophys. Acta 1823:2109-2119(2012) [PubMed] [Europe PMC] [Abstract]
  29. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
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