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Protein Tyrosine Phosphatase, Non Receptor Type 6 (PTPN6)

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HCP; HCPH; HPTP1C; SH-PTP1; SHP-1L; SHP1; Hematopoietic cell protein-tyrosine phosphatase; Protein-tyrosine phosphatase 1C; Protein-tyrosine phosphatase SHP-1

Protein Tyrosine Phosphatase, Non Receptor Type 6 (PTPN6)
CCC D589
HGNC 9658
MGI 96055
PubMed 24327268
RGD 620660
UniProt P29350
Wiki PTPN6
is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD589Hu01 Recombinant Protein Tyrosine Phosphatase, Non Receptor Type 6 (PTPN6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD589Hu01 Polyclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 6 (PTPN6) WB; IHC; ICC; IP.
MAD589Hu21 Monoclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 6 (PTPN6) WB; IHC; ICC; IP.
Assay Kits SED589Hu ELISA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 6 (PTPN6) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Tyrosine Phosphatase, Non Receptor Type 6 (PTPN6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 6 (PTPN6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 6 (PTPN6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 6 (PTPN6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 6 (PTPN6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Tyrosine Phosphatase, Non Receptor Type 6 (PTPN6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 6 (PTPN6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 6 (PTPN6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 6 (PTPN6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 6 (PTPN6) ELISA Kit Customized Service Offer
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  20. "IgSF13, a novel human inhibitory receptor of the immunoglobulin superfamily, is preferentially expressed in dendritic cells and monocytes."Biochem. Biophys. Res. Commun. 319:920-928(2004) [PubMed] [Europe PMC] [Abstract]
  21. "Signal transduction via the stem cell factor receptor/c-Kit."Cell. Mol. Life Sci. 61:2535-2548(2004) [PubMed] [Europe PMC] [Abstract]
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  24. "The nuclear localization of 3'-phosphoinositide-dependent kinase-1 is dependent on its association with the protein tyrosine phosphatase SHP-1."Cell. Signal. 21:1634-1644(2009) [PubMed] [Europe PMC] [Abstract]
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  26. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
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  30. "Solution structures of the SH2 domain of human protein-tyrosine phosphatase SHP-1."Submitted (NOV-2005) to the PDB data bank
  31. "Crystal structure of human protein tyrosine phosphatase SHP-1 in the open conformation."J. Cell. Biochem. 112:2062-2071(2011) [PubMed] [Europe PMC] [Abstract]