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Protein Tyrosine Phosphatase, Non Receptor Type 12 (PTPN12)

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PTP-PEST; PTPG1; Protein-tyrosine phosphatase G1

Protein Tyrosine Phosphatase, Non Receptor Type 12 (PTPN12)
CCC D592
HGNC 9645
MGI 104673
PubMed 24475046
RGD 620894
UniProt Q05209
Wiki PTPN12
Tyrosine-protein phosphatase non-receptor type 12 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may be related to protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of oncogene c-ABL, thus may play a role in oncogenesis. This PTP was shown to interact with, and dephosphorylate, various of cytoskeleton and cell adhesion molecules, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin, which suggested its regulatory roles in controlling cell shape and mobility.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD592Hu01 Recombinant Protein Tyrosine Phosphatase, Non Receptor Type 12 (PTPN12) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD592Hu01 Polyclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 12 (PTPN12) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 12 (PTPN12) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 12 (PTPN12) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD592Mu01 Recombinant Protein Tyrosine Phosphatase, Non Receptor Type 12 (PTPN12) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 12 (PTPN12) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 12 (PTPN12) Polyclonal Antibody Customized Service Offer
Assay Kits SED592Mu ELISA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 12 (PTPN12) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Tyrosine Phosphatase, Non Receptor Type 12 (PTPN12) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 12 (PTPN12) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 12 (PTPN12) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 12 (PTPN12) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 12 (PTPN12) ELISA Kit Customized Service Offer
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  9. "A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion."EMBO J. 17:7320-7336(1998) [PubMed] [Europe PMC] [Abstract]
  10. "Inhibition of cell migration by autophosphorylated mammalian sterile 20-like kinase 3 (MST3) involves paxillin and protein-tyrosine phosphatase-PEST."J. Biol. Chem. 281:38405-38417(2006) [PubMed] [Europe PMC] [Abstract]
  11. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Interaction of Pyk2 and PTP-PEST with leupaxin in prostate cancer cells."Am. J. Physiol. 292:C2288-C2296(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  15. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  20. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  21. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]