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Protein Tyrosine Phosphatase, Non Receptor Type 13 (PTPN13)

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FAP1; PNP1; PTP-BAS; PTP-BL; PTPL1; PTPLE; APO-1/CD95(Fas)-Associated Phosphatase; Fas-associated protein-tyrosine phosphatase 1; Protein-tyrosine phosphatase 1E

Protein Tyrosine Phosphatase, Non Receptor Type 13 (PTPN13)
CCC D593
HGNC 9646
MGI 103293
PubMed 21235435
RGD 1563360
UniProt Q12923
Wiki PTPN13
Tyrosine-protein phosphatase non-receptor type 13 is a member of the protein tyrosine phosphatase (PTP) family. This PTP is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic domains, which include a domain with similarity to band 4.1 superfamily of cytoskeletal-associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. This PTP was found to interact with, and dephosphorylate Fas receptor, as well as IkappaBalpha through the PDZ domains, which suggested its role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathway. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD593Hu01 Recombinant Protein Tyrosine Phosphatase, Non Receptor Type 13 (PTPN13) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD593Hu01 Polyclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 13 (PTPN13) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 13 (PTPN13) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 13 (PTPN13) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD593Mu01 Recombinant Protein Tyrosine Phosphatase, Non Receptor Type 13 (PTPN13) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD593Mu01 Polyclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 13 (PTPN13) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 13 (PTPN13) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 13 (PTPN13) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD593Ra01 Recombinant Protein Tyrosine Phosphatase, Non Receptor Type 13 (PTPN13) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD593Ra01 Polyclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 13 (PTPN13) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 13 (PTPN13) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 13 (PTPN13) ELISA Kit Customized Service Offer
  1. "A novel protein-tyrosine phosphatase with homology to both the cytoskeletal proteins of the band 4.1 family and junction-associated guanylate kinases."J. Biol. Chem. 269:22320-22327(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning of a novel protein-tyrosine phosphatase containing a membrane-binding domain and GLGF repeats."FEBS Lett. 337:200-206(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and characterization of PTPL1, a protein tyrosine phosphatase with similarities to cytoskeletal-associated proteins."J. Biol. Chem. 269:24082-24089(1994) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "FAP-1: a protein tyrosine phosphatase that associates with Fas."Science 268:411-415(1995) [PubMed] [Europe PMC] [Abstract]
  6. "Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation."FEBS Lett. 460:191-198(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of novel protein-tyrosine phosphatases in a human leukemia cell line, F-36P."Leukemia 7:742-746(1993) [PubMed] [Europe PMC] [Abstract]
  8. "A novel GTPase-activating protein for Rho interacts with a PDZ domain of the protein-tyrosine phosphatase PTPL1."J. Biol. Chem. 272:24333-24338(1997) [PubMed] [Europe PMC] [Abstract]
  9. "ZRP-1, a zyxin-related protein, interacts with the second PDZ domain of the cytosolic protein tyrosine phosphatase hPTP1E."J. Biol. Chem. 274:20679-20687(1999) [PubMed] [Europe PMC] [Abstract]
  10. "The protein kinase C-related kinase PRK2 interacts with the protein tyrosine phosphatase PTP-BL via a novel PDZ domain binding motif."FEBS Lett. 496:101-104(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1."Biochem. J. 376:525-535(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "FBXL2- and PTPL1-mediated degradation of p110-free p85beta regulatory subunit controls the PI(3)K signalling cascade."Nat. Cell Biol. 15:472-480(2013) [PubMed] [Europe PMC] [Abstract]
  16. "The serologically defined colon cancer antigen-3 interacts with the protein tyrosine phosphatase PTPN13 and is involved in the regulation of cytokinesis."Oncogene 32:4602-4613(2013) [PubMed] [Europe PMC] [Abstract]
  17. "Solution structure of the PDZ2 domain from human phosphatase hPTP1E and its interactions with C-terminal peptides from the Fas receptor."Biochemistry 39:2572-2580(2000) [PubMed] [Europe PMC] [Abstract]
  18. "Solution structure of the PDZ2 domain from cytosolic human phosphatase hPTP1E complexed with a peptide reveals contribution of the beta2-beta3 loop to PDZ domain-ligand interactions."J. Mol. Biol. 320:813-820(2002) [PubMed] [Europe PMC] [Abstract]
  19. "Crystal structure of the PTPL1/FAP-1 human tyrosine phosphatase mutated in colorectal cancer: evidence for a second phosphotyrosine substrate recognition pocket."J. Biol. Chem. 280:8180-8187(2005) [PubMed] [Europe PMC] [Abstract]
  20. "Head-to-head juxtaposition of Fas-associated phosphatase-1 (FAP-1) and c-Jun NH2-terminal kinase 3 (JNK3) genes: genomic structure and seven polymorphisms of the FAP-1 gene."J. Hum. Genet. 47:614-619(2002) [PubMed] [Europe PMC] [Abstract]