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Protein Tyrosine Phosphatase, Non Receptor Type 23 (PTPN23)

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HD-PTP; HDPTP; PTP-TD14; His domain-containing protein tyrosine phosphatase; Protein tyrosine phosphatase TD14

Protein Tyrosine Phosphatase, Non Receptor Type 23 (PTPN23)
CCC D598
HGNC 14406
MGI 2144837
PubMed 21724833
RGD 619892
UniProt Q9H3S7
Wiki PTPN23
PTPN23, from a gastric cancer cell line. The predicted protein contains at least 1,636 amino acids and has several features distinct from those in previously identified PTPs, the most striking of which is the sequence VHCSSG instead of the invariant VHCSAG sequence at the PTP active center. PTPN23 contains a zinc-hand domain, which the authors called a 'His domain' (HD); several SH3-binding motifs; a tyrosine phosphatase domain; a C-terminal PEST motif; and an N-terminal domain similar to yeast BRO1, mouse rhophilin, and human AIP1. It appears to be the homolog of rat PTP-TD14 which has been found to inhibit activated H-ras-mediated cell transformation. Northern blot analysis in rat revealed ubiquitous expression of a 6-kb PTPN23 transcript.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Tyrosine Phosphatase, Non Receptor Type 23 (PTPN23) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 23 (PTPN23) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 23 (PTPN23) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 23 (PTPN23) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 23 (PTPN23) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Tyrosine Phosphatase, Non Receptor Type 23 (PTPN23) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 23 (PTPN23) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 23 (PTPN23) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 23 (PTPN23) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 23 (PTPN23) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Tyrosine Phosphatase, Non Receptor Type 23 (PTPN23) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 23 (PTPN23) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 23 (PTPN23) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 23 (PTPN23) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 23 (PTPN23) ELISA Kit Customized Service Offer
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  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
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  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "The Bro1-related protein HD-PTP/PTPN23 is required for endosomal cargo sorting and multivesicular body morphogenesis."Proc. Natl. Acad. Sci. U.S.A. 105:6308-6313(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Functional genomic screen for modulators of ciliogenesis and cilium length."Nature 464:1048-1051(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpL."PLoS ONE 5:E14339-E14339(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "UBAP1 is a component of an endosome-specific ESCRT-I complex that is essential for MVB sorting."Curr. Biol. 21:1245-1250(2011) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "The Phe105 loop of Alix Bro1 domain plays a key role in HIV-1 release."Structure 19:1485-1495(2011) [PubMed] [Europe PMC] [Abstract]