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Protein Tyrosine Phosphatase Receptor Type A (PTPRA)

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PTPR-A; LRP; PTPA; HEPTP; HLPR; HPTPA; HPTPalpha; PTPRL2; R-PTP-alpha; RPTPA; Receptor-type tyrosine-protein phosphatase alpha

Protein Tyrosine Phosphatase Receptor Type A (PTPRA)
CCC D599
HGNC 9664
MGI 97808
PubMed 8790445
RGD 3450
UniProt P18433
Wiki PTPRA
Receptor-type tyrosine-protein phosphatase alpha is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.
This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD599Hu01 Recombinant Protein Tyrosine Phosphatase Receptor Type A (PTPRA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD599Hu01 Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type A (PTPRA) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase Receptor Type A (PTPRA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase Receptor Type A (PTPRA) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Tyrosine Phosphatase Receptor Type A (PTPRA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Tyrosine Phosphatase Receptor Type A (PTPRA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type A (PTPRA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase Receptor Type A (PTPRA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase Receptor Type A (PTPRA) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD599Ra01 Recombinant Protein Tyrosine Phosphatase Receptor Type A (PTPRA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD599Ra01 Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type A (PTPRA) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase Receptor Type A (PTPRA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase Receptor Type A (PTPRA) ELISA Kit Customized Service Offer
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  2. "Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain."Proc. Natl. Acad. Sci. U.S.A. 87:7000-7004(1990) [PubMed] [Europe PMC] [Abstract]
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  5. "Cloning and chromosomal assignment of a widely expressed human receptor-like protein-tyrosine phosphatase."FEBS Lett. 273:239-242(1990) [PubMed] [Europe PMC] [Abstract]
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  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]