Protein Tyrosine Phosphatase Receptor Type Q (PTPRQ)
[Edit]PTPR-Q; Phosphatidylinositol phosphatase PTPRQ
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PTPRQ belongs to the type III receptor-like protein-tyrosine phosphatase (PTPase) family. PTPRQ has low activity against phosphotyrosine, but is active against phosphatidylinositol phosphates that are involved in regulation of survival, proliferation, and subcellular architecture. The genomic region containing nt 391..910 of this sequence are inverted in the human reference genome (build 37). This portion of the RefSeq is inferred based on alignments of rat and mouse transcripts, and is supported by the human Celera assembly.
In developing kidney, it localizes to the basal membrane of podocytes, beginning when podocyte progenitors can first be identified in the embryonic kidney (at protein level). Expressed in lung and kidney.
In developing kidney, it localizes to the basal membrane of podocytes, beginning when podocyte progenitors can first be identified in the embryonic kidney (at protein level). Expressed in lung and kidney.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPD603Hu01 | Recombinant Protein Tyrosine Phosphatase Receptor Type Q (PTPRQ) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAD603Hu01 | Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type Q (PTPRQ) | WB; IHC; ICC; IP. |
| MAD603Hu21 | Monoclonal Antibody to Protein Tyrosine Phosphatase Receptor Type Q (PTPRQ) | WB; IHC; ICC; IP. | |
| Assay Kits | SED603Hu | ELISA Kit for Protein Tyrosine Phosphatase Receptor Type Q (PTPRQ) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Protein Tyrosine Phosphatase Receptor Type Q (PTPRQ) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Protein Tyrosine Phosphatase Receptor Type Q (PTPRQ) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type Q (PTPRQ) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Protein Tyrosine Phosphatase Receptor Type Q (PTPRQ) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Protein Tyrosine Phosphatase Receptor Type Q (PTPRQ) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Protein Tyrosine Phosphatase Receptor Type Q (PTPRQ) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Protein Tyrosine Phosphatase Receptor Type Q (PTPRQ) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type Q (PTPRQ) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Protein Tyrosine Phosphatase Receptor Type Q (PTPRQ) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Protein Tyrosine Phosphatase Receptor Type Q (PTPRQ) | ELISA Kit Customized Service Offer |
- "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
- "PTPRQ is a novel phosphatidylinositol phosphatase that can be expressed as a cytoplasmic protein or as a subcellularly localized receptor-like protein."Exp. Cell Res. 287:374-386(2003) [PubMed] [Europe PMC] [Abstract]
- "Involvement of PTP-RQ in differentiation during adipogenesis of human mesenchymal stem cells."Biochem. Biophys. Res. Commun. 383:252-257(2009) [PubMed] [Europe PMC] [Abstract]
- "Mutations in PTPRQ are a cause of autosomal-recessive nonsyndromic hearing impairment DFNB84 and associated with vestibular dysfunction."Am. J. Hum. Genet. 86:604-610(2010) [PubMed] [Europe PMC] [Abstract]
- "Nonsense mutation of the stereociliar membrane protein gene PTPRQ in human hearing loss DFNB84."J. Med. Genet. 47:643-645(2010) [PubMed] [Europe PMC] [Abstract]