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Protein Tyrosine Phosphatase Receptor Type U (PTPRU)

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PTPRO; GLEPP1; PTPU2; PTP; FMI; PCP-2; PTP-J; PTP-PI; PTPPSI; R-PTP-PSI; hPTP-J; Pancreatic carcinoma phosphatase 2; Protein-tyrosine phosphatase receptor omicron

Protein Tyrosine Phosphatase Receptor Type U (PTPRU)
CCC D605
HGNC 9683
MGI 1321151
PubMed 19515692
RGD 620782
UniProt Q92729
Wiki PTPRU
Receptor-type tyrosine-protein phosphatase U is a member of the protein tyrosine phosphatase (PTP) family. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Three alternatively spliced transcript variants, which encode distinct proteins, have been reported.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD605Hu01 Recombinant Protein Tyrosine Phosphatase Receptor Type U (PTPRU) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD605Hu01 Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type U (PTPRU) WB; IHC; ICC; IP.
Assay Kits SED605Hu ELISA Kit for Protein Tyrosine Phosphatase Receptor Type U (PTPRU) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Tyrosine Phosphatase Receptor Type U (PTPRU) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Tyrosine Phosphatase Receptor Type U (PTPRU) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type U (PTPRU) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase Receptor Type U (PTPRU) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase Receptor Type U (PTPRU) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Tyrosine Phosphatase Receptor Type U (PTPRU) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Tyrosine Phosphatase Receptor Type U (PTPRU) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type U (PTPRU) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase Receptor Type U (PTPRU) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase Receptor Type U (PTPRU) ELISA Kit Customized Service Offer
  1. "Molecular cloning and characterization of PTP pi, a novel receptor-like protein-tyrosine phosphatase."Biochem. J. 319:249-254(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of PCP-2, a novel receptor protein tyrosine phosphatase of the MAM domain family."Oncogene 12:2555-2562(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning and characterization of a novel human receptor protein tyrosine phosphatase gene, hPTP-J: down-regulation of gene expression by PMA and calcium ionophore in Jurkat T lymphoma cells."Biochem. Biophys. Res. Commun. 231:77-81(1997) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization and chromosomal localization of PTPRO, a novel receptor protein tyrosine phosphatase, expressed in hematopoietic stem cells."Gene 204:5-16(1997) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Transcriptional regulation of a receptor protein tyrosine phosphatase gene hPTP-J by PKC-mediated signaling pathways in Jurkat and Molt-4 T lymphoma cells."Biochim. Biophys. Acta 1450:331-340(1999) [PubMed] [Europe PMC] [Abstract]
  8. "The receptor protein tyrosine phosphatase, PTP-RO, is upregulated during megakaryocyte differentiation and is associated with the c-Kit receptor."Blood 94:539-549(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Physical and functional interaction between receptor-like protein tyrosine phosphatase PCP-2 and beta-catenin."Biochemistry 41:15854-15860(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Protein-tyrosine phosphatase PCP-2 inhibits beta-catenin signaling and increases E-cadherin-dependent cell adhesion."J. Biol. Chem. 281:15423-15433(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Involvement of beta3A subunit of adaptor protein-3 in intracellular trafficking of receptor-like protein tyrosine phosphatase PCP-2."Acta Biochim. Biophys. Sin. 39:540-546(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]