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Protein Tyrosine Phosphatase Receptor Type Z (PTPRZ)

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PTPRZ1; HPTPZ; HPTPzeta; PTP18; PTPR-Z; PTPZ; RPTPB; RPTPbeta; Phosphacan; Receptor-type tyrosine-protein phosphatase zeta

Protein Tyrosine Phosphatase Receptor Type Z (PTPRZ)
CCC D607
HGNC 9685
MGI 97816
PubMed 20133774
RGD 3455
UniProt P23471
Receptor-type tyrosine-protein phosphatase zeta is a member of the receptor type protein tyrosine phosphatase family and encodes a single-pass type I membrane protein with two cytoplasmic tyrosine-protein phosphatase domains, an alpha-carbonic anhydrase domain and a fibronectin type-III domain.
Expression of this gene is induced in gastric cancer cells, in the remyelinating oligodendrocytes of multiple sclerosis lesions, and in human embryonic kidney cells under hypoxic conditions. Both the protein and transcript are overexpressed in glioblastoma cells, promoting their haptotactic migration. Alternative splice variants that encode different protein isoforms have been described but their full-length nature has not been determined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD607Hu01 Recombinant Protein Tyrosine Phosphatase Receptor Type Z (PTPRZ) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD607Hu01 Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type Z (PTPRZ) WB
Assay Kits SED607Hu ELISA Kit for Protein Tyrosine Phosphatase Receptor Type Z (PTPRZ) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD607Mu01 Recombinant Protein Tyrosine Phosphatase Receptor Type Z (PTPRZ) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD607Mu01 Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type Z (PTPRZ) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase Receptor Type Z (PTPRZ) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase Receptor Type Z (PTPRZ) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Tyrosine Phosphatase Receptor Type Z (PTPRZ) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Tyrosine Phosphatase Receptor Type Z (PTPRZ) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type Z (PTPRZ) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase Receptor Type Z (PTPRZ) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase Receptor Type Z (PTPRZ) ELISA Kit Customized Service Offer
  1. "A human transmembrane protein-tyrosine-phosphatase, PTP zeta, is expressed in brain and has an N-terminal receptor domain homologous to carbonic anhydrases."Proc. Natl. Acad. Sci. U.S.A. 89:7417-7421(1992) [PubMed] [Europe PMC] [Abstract]
  2. "The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system."J. Biol. Chem. 268:10573-10581(1993) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Molecular cloning and expression analysis of five novel genes in chromosome 1p36."Genomics 50:187-198(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Structural diversity and evolution of human receptor-like protein tyrosine phosphatases."EMBO J. 9:3241-3252(1990) [PubMed] [Europe PMC] [Abstract]
  7. "Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain."Proc. Natl. Acad. Sci. U.S.A. 87:7000-7004(1990) [PubMed] [Europe PMC] [Abstract]
  8. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  10. "The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules."Proc. Natl. Acad. Sci. U.S.A. 107:2443-2448(2010) [PubMed] [Europe PMC] [Abstract]