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Protein Tyrosine Phosphatase F Interacting Protein 1 (PPFIA1)

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LIP.1; LIP1; LIPRIN; Liprin-Alpha 1; LAR-interacting protein 1; Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1

Protein Tyrosine Phosphatase F Interacting Protein 1 (PPFIA1)
CCC D614
HGNC 9245
MGI 1924750
PubMed 18196592
RGD 1309009
UniProt Q13136
Wiki PPFIA1
Liprin-alpha-1 is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development.
This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD614Hu01 Recombinant Protein Tyrosine Phosphatase F Interacting Protein 1 (PPFIA1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD614Hu01 Polyclonal Antibody to Protein Tyrosine Phosphatase F Interacting Protein 1 (PPFIA1) WB,ICC/IF
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase F Interacting Protein 1 (PPFIA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase F Interacting Protein 1 (PPFIA1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Tyrosine Phosphatase F Interacting Protein 1 (PPFIA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Tyrosine Phosphatase F Interacting Protein 1 (PPFIA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Tyrosine Phosphatase F Interacting Protein 1 (PPFIA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase F Interacting Protein 1 (PPFIA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase F Interacting Protein 1 (PPFIA1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Tyrosine Phosphatase F Interacting Protein 1 (PPFIA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Tyrosine Phosphatase F Interacting Protein 1 (PPFIA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Tyrosine Phosphatase F Interacting Protein 1 (PPFIA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase F Interacting Protein 1 (PPFIA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase F Interacting Protein 1 (PPFIA1) ELISA Kit Customized Service Offer
  1. "The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions."EMBO J. 14:2827-2838(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1."Proc. Natl. Acad. Sci. U.S.A. 92:11686-11690(1995) [PubMed] [Europe PMC] [Abstract]
  5. "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins."J. Biol. Chem. 273:15611-15620(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]