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ATP Binding Cassette Transporter C3 (ABCC3)

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ABC31; MLP2; MOATD; MRP3; cMOAT2; Canalicular Multispecific Organic Anion Transporter 2; Multi-specific organic anion transporter D; Multidrug resistance-associated protein 3

ATP Binding Cassette Transporter C3 (ABCC3)
CCC D623
HGNC 54
MGI 1923658
PubMed 22585709
RGD 71101
UniProt O15438
Wiki ABCC3
Canalicular multispecific organic anion transporter 2 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD623Hu01 Recombinant ATP Binding Cassette Transporter C3 (ABCC3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD623Hu01 Polyclonal Antibody to ATP Binding Cassette Transporter C3 (ABCC3) WB; ICC; IHC-P; IHC-F; ELISA.
MAD623Hu21 Monoclonal Antibody to ATP Binding Cassette Transporter C3 (ABCC3) WB; IHC; ICC; IP.
Assay Kits SED623Hu ELISA Kit for ATP Binding Cassette Transporter C3 (ABCC3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATP Binding Cassette Transporter C3 (ABCC3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATP Binding Cassette Transporter C3 (ABCC3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATP Binding Cassette Transporter C3 (ABCC3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ATP Binding Cassette Transporter C3 (ABCC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATP Binding Cassette Transporter C3 (ABCC3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATP Binding Cassette Transporter C3 (ABCC3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATP Binding Cassette Transporter C3 (ABCC3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATP Binding Cassette Transporter C3 (ABCC3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ATP Binding Cassette Transporter C3 (ABCC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATP Binding Cassette Transporter C3 (ABCC3) ELISA Kit Customized Service Offer
  1. "Isolation of a novel human canalicular multispecific organic anion transporter, cMOAT2/MRP3, and its expression in cisplatin-resistant cancer cells with decreased ATP-dependent drug transport."Biochem. Biophys. Res. Commun. 252:103-110(1998) [PubMed] [Europe PMC] [Abstract]
  2. "cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3)."FEBS Lett. 433:149-152(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins."J. Natl. Cancer Inst. 90:1735-1741(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Human MRP3 transporter: identification of the 5'-flanking region, genomic organization and alternative splice variants."Biochim. Biophys. Acta 1415:369-374(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane."Hepatology 29:1156-1163(1999) [PubMed] [Europe PMC] [Abstract]
  6. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines."Cancer Res. 57:3537-3547(1997) [PubMed] [Europe PMC] [Abstract]
  9. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]