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ATP Dependent DNA ligase II (LIG2)

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LIG3; Ligase III; Polydeoxyribonucleotide synthase [ATP] 3

ATP Dependent DNA ligase II (LIG2)
CCC D627
HGNC 6600
MGI 109152
PubMed 24442571
RGD 1309875
UniProt P49916
Wiki LIG3
The LIG3 cDNA encodes a polypeptide of 862 amino acids, whose sequence is more closely related to those of the DNA ligases encoded by poxviruses than to replicative DNA ligases, such as human DNA ligase I. Amino acid sequencing studies indicated that these enzymes are encoded by the same gene.
Downregulation of LIG3 impaired removal of ultraviolet (UV)-induced lesions and rejoining of UV-induced nicks in chromosomal DNA. Moreover, XRCC1-LIG3 and polymerase-delta (POLD1) interacted and colocalized with NER components in a UV-specific manner throughout interphase. In contrast, recruitment of LIG1 and polymerase-epsilon (POLE) to UV-irradiated sites was only observed in proliferating cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATP Dependent DNA ligase II (LIG2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATP Dependent DNA ligase II (LIG2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATP Dependent DNA ligase II (LIG2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ATP Dependent DNA ligase II (LIG2) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATP Dependent DNA ligase II (LIG2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATP Dependent DNA ligase II (LIG2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATP Dependent DNA ligase II (LIG2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATP Dependent DNA ligase II (LIG2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ATP Dependent DNA ligase II (LIG2) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATP Dependent DNA ligase II (LIG2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATP Dependent DNA ligase II (LIG2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATP Dependent DNA ligase II (LIG2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATP Dependent DNA ligase II (LIG2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ATP Dependent DNA ligase II (LIG2) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATP Dependent DNA ligase II (LIG2) ELISA Kit Customized Service Offer
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  2. "Mammalian DNA ligase III: molecular cloning, chromosomal localization, and expression in spermatocytes undergoing meiotic recombination."Mol. Cell. Biol. 15:5412-5422(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing."Nucleic Acids Res. 39:44-58(2011) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The human DNA ligase III gene encodes nuclear and mitochondrial proteins."Mol. Cell. Biol. 19:3869-3876(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  8. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Overexpression of DNA ligase III in mitochondria protects cells against oxidative stress and improves mitochondrial DNA base excision repair."DNA Repair 16:44-53(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Expression, purification, and biophysical characterization of the BRCT domain of human DNA ligase IIIalpha."Protein Expr. Purif. 21:401-411(2001) [PubMed] [Europe PMC] [Abstract]
  17. "Solution structure and DNA binding of the zinc-finger domain from DNA ligase IIIalpha."J. Mol. Biol. 341:723-738(2004) [PubMed] [Europe PMC] [Abstract]
  18. "Human DNA ligase III recognizes DNA ends by dynamic switching between two DNA-bound states."Biochemistry 49:6165-6176(2010) [PubMed] [Europe PMC] [Abstract]
  19. "The structural basis for partitioning of the XRCC1/DNA ligase III-? BRCT-mediated dimer complexes."Nucleic Acids Res. 39:7816-7827(2011) [PubMed] [Europe PMC] [Abstract]
  20. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]