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ATP Binding Cassette Transporter B4 (ABCB4)

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ABC-B4; ABC21; MDR2/3; MDR3; PFIC-3; PGY3; GBD1; Multidrug resistance protein 3; P-glycoprotein 3

ATP Binding Cassette Transporter B4 (ABCB4)
CCC D634
HGNC 45
MGI 97569
PubMed 12891548
RGD 620248
UniProt P21439
Wiki ABCB4
Multidrug resistance protein 3 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD634Hu01 Recombinant ATP Binding Cassette Transporter B4 (ABCB4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD634Hu01 Polyclonal Antibody to ATP Binding Cassette Transporter B4 (ABCB4) WB; IHC; ICC; IP.
Assay Kits SED634Hu ELISA Kit for ATP Binding Cassette Transporter B4 (ABCB4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD634Mu01 Recombinant ATP Binding Cassette Transporter B4 (ABCB4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD634Mu01 Polyclonal Antibody to ATP Binding Cassette Transporter B4 (ABCB4) WB; IHC; ICC; IP.
Assay Kits SED634Mu ELISA Kit for ATP Binding Cassette Transporter B4 (ABCB4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATP Binding Cassette Transporter B4 (ABCB4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATP Binding Cassette Transporter B4 (ABCB4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATP Binding Cassette Transporter B4 (ABCB4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ATP Binding Cassette Transporter B4 (ABCB4) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATP Binding Cassette Transporter B4 (ABCB4) ELISA Kit Customized Service Offer
  1. "Sequence of mdr3 cDNA encoding a human P-glycoprotein."Gene 71:401-411(1988) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization of the promoter region of the human MDR3 P-glycoprotein gene."Biochim. Biophys. Acta 1261:44-56(1995) [PubMed] [Europe PMC] [Abstract]
  5. "The human mdr3 gene encodes a novel P-glycoprotein homologue and gives rise to alternatively spliced mRNAs in liver."EMBO J. 6:3325-3331(1987) [PubMed] [Europe PMC] [Abstract]
  6. "Structure of the human MDR3 gene and physical mapping of the human MDR locus."J. Biol. Chem. 266:5303-5310(1991) [PubMed] [Europe PMC] [Abstract]
  7. "Mutations in the MDR3 gene cause progressive familial intrahepatic cholestasis."Proc. Natl. Acad. Sci. U.S.A. 95:282-287(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Heterozygous MDR3 missense mutation associated with intrahepatic cholestasis of pregnancy: evidence for a defect in protein trafficking."Hum. Mol. Genet. 9:1209-1217(2000) [PubMed] [Europe PMC] [Abstract]
  9. "The wide spectrum of multidrug resistance 3 deficiency: from neonatal cholestasis to cirrhosis of adulthood."Gastroenterology 120:1448-1458(2001) [PubMed] [Europe PMC] [Abstract]
  10. "MDR3 gene defect in adults with symptomatic intrahepatic and gallbladder cholesterol cholelithiasis."Gastroenterology 120:1459-1467(2001) [PubMed] [Europe PMC] [Abstract]
  11. "A multidrug resistance 3 gene mutation causing cholelithiasis, cholestasis of pregnancy, and adulthood biliary cirrhosis."Gastroenterology 124:1037-1042(2003) [PubMed] [Europe PMC] [Abstract]
  12. "ABCB4 gene mutation-associated cholelithiasis in adults."Gastroenterology 125:452-459(2003) [PubMed] [Europe PMC] [Abstract]
  13. "ABCB4 gene sequence variation in women with intrahepatic cholestasis of pregnancy."J. Med. Genet. 40:E70-E70(2003) [PubMed] [Europe PMC] [Abstract]
  14. "Sequence analysis of bile salt export pump (ABCB11) and multidrug resistance p-glycoprotein 3 (ABCB4, MDR3) in patients with intrahepatic cholestasis of pregnancy."Pharmacogenetics 14:91-102(2004) [PubMed] [Europe PMC] [Abstract]
  15. "Genetic variability, haplotype structures, and ethnic diversity of hepatic transporters MDR3 (ABCB4) and bile salt export pump (ABCB11)."Drug Metab. Dispos. 34:1582-1599(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injury."Pharmacogenet. Genomics 17:47-60(2007) [PubMed] [Europe PMC] [Abstract]