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ATP Binding Cassette Transporter B5 (ABCB5)

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ABC-B5; P-Glycoprotein ABCB5; ATP-Binding Cassette Protein

ATP Binding Cassette Transporter B5 (ABCB5)
CCC D635
HGNC 46
MGI 1924956
PubMed 21652540
RGD 1566342
UniProt Q2M3G0
Wiki ABCB5
ABCB5 [ATP-Binding Cassette Subfamily B (MDR/TAP) Member 5] is a human ABC transporter and P-glycoprotein family member principally expressed in physiological skin and human malignant melanoma.ABCB5-alpha and -beta diverge after exon 6, with ABCB5-alpha including a seventh exon that encodes its 3-prime UTR, and ABCB5-beta including 14 more exons. The 131-amino acid ABCB5-alpha protein has a calculated molecular mass of 15 kD. It has an ABC signature motif and a Walker B consensus sequence, but no Walker A consensus sequence. In contrast, ABCB5-beta has an N-terminal ABC signature motif and Walker B motif, followed by 6 transmembrane domains and C-terminal Walker A, ABC signature, and Walker B motifs.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD635Hu01 Recombinant ATP Binding Cassette Transporter B5 (ABCB5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD635Hu01 Polyclonal Antibody to ATP Binding Cassette Transporter B5 (ABCB5) WB; IHC; ICC; IP.
MAD635Hu21 Monoclonal Antibody to ATP Binding Cassette Transporter B5 (ABCB5) WB; IHC; ICC; IP.
Assay Kits SED635Hu ELISA Kit for ATP Binding Cassette Transporter B5 (ABCB5) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATP Binding Cassette Transporter B5 (ABCB5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATP Binding Cassette Transporter B5 (ABCB5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATP Binding Cassette Transporter B5 (ABCB5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ATP Binding Cassette Transporter B5 (ABCB5) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATP Binding Cassette Transporter B5 (ABCB5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATP Binding Cassette Transporter B5 (ABCB5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATP Binding Cassette Transporter B5 (ABCB5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATP Binding Cassette Transporter B5 (ABCB5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ATP Binding Cassette Transporter B5 (ABCB5) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATP Binding Cassette Transporter B5 (ABCB5) ELISA Kit Customized Service Offer
  1. "Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter."J. Biol. Chem. 278:47156-47165(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Principal expression of two mRNA isoforms (ABCB 5alpha and ABCB 5beta) of the ATP-binding cassette transporter gene ABCB 5 in melanoma cells and melanocytes."Pigment Cell Res. 18:102-112(2005) [PubMed] [Europe PMC] [Abstract]
  3. "ABCB5 identifies a therapy-refractory tumor cell population in colorectal cancer patients."Cancer Res. 71:5307-5316(2011) [PubMed] [Europe PMC] [Abstract]
  4. "Expression of human ABCB5 confers resistance to taxanes and anthracyclines."Biochem. Biophys. Res. Commun. 418:736-741(2012) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Membrane transporters and channels: role of the transportome in cancer chemosensitivity and chemoresistance."Cancer Res. 64:4294-4301(2004) [PubMed] [Europe PMC] [Abstract]
  9. "ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma."Cancer Res. 65:4320-4333(2005) [PubMed] [Europe PMC] [Abstract]
  10. "ABCB5 expression and cancer stem cell hypothesis in oral squamous cell carcinoma."Eur. J. Cancer 48:3186-3197(2012) [PubMed] [Europe PMC] [Abstract]
  11. "Expression of ABCB5 gene in hematological malignances and its significance."Leuk. Lymphoma 53:1211-1215(2012) [PubMed] [Europe PMC] [Abstract]
  12. "Melanoma chemotherapy leads to the selection of ABCB5-expressing cells."PLoS ONE 7:E36762-E36762(2012) [PubMed] [Europe PMC] [Abstract]
  13. "Genetically determined ABCB5 functionality correlates with pigmentation phenotype and melanoma risk."Biochem. Biophys. Res. Commun. 436:536-542(2013) [PubMed] [Europe PMC] [Abstract]
  14. "ABCB5 maintains melanoma-initiating cells through a pro-inflammatory cytokine signaling circuit."Cancer Res. 74:4196-4207(2014) [PubMed] [Europe PMC] [Abstract]
  15. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Core signaling pathways in human pancreatic cancers revealed by global genomic analyses." Science 321:1801-1806(2008) [PubMed] [Europe PMC] [Abstract]
  17. "ABCB5 is a limbal stem cell gene required for corneal development and repair." Nature 511:353-357(2014) [PubMed] [Europe PMC] [Abstract]