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ATP Binding Cassette Transporter B6 (ABCB6)

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ABC-B6; PRP; ABC; ABC14; MTABC3; Umat; ATP-Binding Cassette Half-Transporter; P-glycoprotein-related protein; Ubiquitously-expressed mammalian ABC half transporter

ATP Binding Cassette Transporter B6 (ABCB6)
CCC D636
HGNC 47
MGI 1921354
PubMed 11977179
RGD 71077
UniProt Q9NP58
Wiki ABCB6
ATP-binding cassette sub-family B member 6, mitochondrial is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This half-transporter likely plays a role in mitochondrial function. Localized to 2q26, this gene is considered a candidate gene for lethal neonatal metabolic syndrome, a disorder of mitochondrial function.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD636Hu01 Recombinant ATP Binding Cassette Transporter B6 (ABCB6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD636Hu01 Polyclonal Antibody to ATP Binding Cassette Transporter B6 (ABCB6) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for ATP Binding Cassette Transporter B6 (ABCB6) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATP Binding Cassette Transporter B6 (ABCB6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATP Binding Cassette Transporter B6 (ABCB6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATP Binding Cassette Transporter B6 (ABCB6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATP Binding Cassette Transporter B6 (ABCB6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ATP Binding Cassette Transporter B6 (ABCB6) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATP Binding Cassette Transporter B6 (ABCB6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATP Binding Cassette Transporter B6 (ABCB6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATP Binding Cassette Transporter B6 (ABCB6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATP Binding Cassette Transporter B6 (ABCB6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ATP Binding Cassette Transporter B6 (ABCB6) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATP Binding Cassette Transporter B6 (ABCB6) ELISA Kit Customized Service Offer
  1. "MTABC3, a novel mitochondrial ATP-binding cassette protein involved in iron homeostasis."J. Biol. Chem. 275:17536-17540(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation of a genomic clone containing the promoter region of the human ATP binding cassette (ABC) transporter, ABCB6."Biochim. Biophys. Acta 1574:117-130(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of a mammalian mitochondrial porphyrin transporter."Nature 443:586-589(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Human ABCB6 localizes to both the outer mitochondrial membrane and the plasma membrane."Biochemistry 46:9443-9452(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Human ABC transporter isoform B6 (ABCB6) localizes primarily in the Golgi apparatus."Biochem. Biophys. Res. Commun. 369:369-375(2008) [PubMed] [Europe PMC] [Abstract]
  8. "ABCB6 mutations cause ocular coloboma." Am. J. Hum. Genet. 90:40-48(2012) [PubMed] [Europe PMC] [Abstract]
  9. "ABCB6 is dispensable for erythropoiesis and specifies the new blood group system Langereis."Nat. Genet. 44:170-173(2012) [PubMed] [Europe PMC] [Abstract]
  10. "Missense mutations in the ABCB6 transporter cause dominant familial pseudohyperkalemia."Am. J. Hematol. 88:66-72(2013) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "Heteronuclear multidimensional NMR and homology modelling studies of the C-terminal nucleotide-binding domain of the human mitochondrial ABC transporter ABCB6."J. Biomol. NMR 35:53-71(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Structures of the nucleotide-binding domain of the human ABCB6 transporter and its complexes with nucleotides."Acta Crystallogr. D 66:979-987(2010) [PubMed] [Europe PMC] [Abstract]
  14. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Mutations in ABCB6 cause dyschromatosis universalis hereditaria." J. Invest. Dermatol. 133:2221-2228(2013) [PubMed] [Europe PMC] [Abstract]
  16. "Novel mutations of ABCB6 associated with autosomal dominant dyschromatosis universalis hereditaria."PLoS ONE 8:E79808-E79808(2013) [PubMed] [Europe PMC] [Abstract]
  17. "Genome-wide linkage, exome sequencing and functional analyses identify ABCB6 as the pathogenic gene of dyschromatosis universalis hereditaria." PLoS ONE 9:E87250-E87250(2014) [PubMed] [Europe PMC] [Abstract]