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ATP Binding Cassette Transporter B9 (ABCB9)

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ABC-B9; TAPL; TAP-like protein

ATP Binding Cassette Transporter B9 (ABCB9)
CCC D639
HGNC 50
MGI 1861729
PubMed 10748049
RGD 620254
UniProt Q9NP78
Wiki ABCB9
ATP-binding cassette sub-family B member 9 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, this protein may play a role in lysosomes. Alternative splicing of this gene results in distinct isoforms which are likely to have different substrate specifications.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD639Hu01 Recombinant ATP Binding Cassette Transporter B9 (ABCB9) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD639Hu01 Polyclonal Antibody to ATP Binding Cassette Transporter B9 (ABCB9) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for ATP Binding Cassette Transporter B9 (ABCB9) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATP Binding Cassette Transporter B9 (ABCB9) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD639Mu01 Recombinant ATP Binding Cassette Transporter B9 (ABCB9) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD639Mu01 Polyclonal Antibody to ATP Binding Cassette Transporter B9 (ABCB9) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for ATP Binding Cassette Transporter B9 (ABCB9) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATP Binding Cassette Transporter B9 (ABCB9) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATP Binding Cassette Transporter B9 (ABCB9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATP Binding Cassette Transporter B9 (ABCB9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATP Binding Cassette Transporter B9 (ABCB9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ATP Binding Cassette Transporter B9 (ABCB9) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATP Binding Cassette Transporter B9 (ABCB9) ELISA Kit Customized Service Offer
  1. "A half-type ABC transporter TAPL is highly conserved between rodent and man, and the human gene is not responsive to interferon-gamma in contrast to TAP1 and TAP2."J. Biochem. 128:711-718(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of ABCB9, an ATP binding cassette protein associated with lysosomes."J. Biol. Chem. 275:23287-23294(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Gene organization of human transporter associated with antigen processing-like (TAPL, ABCB9): analysis of alternative splicing variants and promoter activity."Biochem. Biophys. Res. Commun. 309:815-822(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Alternative splice variants encoding unstable protein domains exist in the human brain."J. Mol. Biol. 343:1207-1220(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Membrane localization of transporter associated with antigen processing (TAP)-like (ABCB9) visualized in vivo with a fluorescence protein-fusion technique."Biol. Pharm. Bull. 27:1916-1922(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Selective and ATP-dependent translocation of peptides by the homodimeric ATP binding cassette transporter TAP-like (ABCB9)."J. Biol. Chem. 280:23631-23636(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Identification of a lysosomal peptide transport system induced during dendritic cell development."J. Biol. Chem. 282:37836-37843(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Integral and associated lysosomal membrane proteins."Traffic 8:1676-1686(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Functional dissection of transmembrane domains of human TAP-like (ABCB9)."Biochem. Biophys. Res. Commun. 377:847-851(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Biochemical characterization of transporter associated with antigen processing (TAP)-like (ABCB9) expressed in insect cells."Biol. Pharm. Bull. 31:1-5(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Peptide specificity and lipid activation of the lysosomal transport complex ABCB9 (TAPL)."J. Biol. Chem. 283:17083-17091(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Tuning the cellular trafficking of the lysosomal peptide transporter TAPL by its N-terminal domain."Traffic 11:383-393(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Transporter associated with antigen processing-like (ABCB9) stably expressed in Chinese hamster ovary-K1 cells is sorted to the microdomains of lysosomal membranes."Biol. Pharm. Bull. 34:36-40(2011) [PubMed] [Europe PMC] [Abstract]
  18. "Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population."J. Hum. Genet. 47:38-50(2002) [PubMed] [Europe PMC] [Abstract]