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Acyl Coenzyme A Dehydrogenase, Long Chain (ACADL)

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LCAD; ACAD4; Long-chain specific acyl-CoA dehydrogenase, mitochondrial

Acyl Coenzyme A Dehydrogenase, Long Chain (ACADL)
CCC D661
HGNC 88
MGI 87866
PubMed 22386849
RGD 2011
UniProt P28330
Wiki ACADL
ACADL is a protein belongs to the acyl-CoA dehydrogenase family, which is a family of mitochondrial flavoenzymes involved in fatty acid and branched chain amino-acid metabolism. This protein is one of the four enzymes that catalyze the initial step of mitochondrial beta-oxidation of straight-chain fatty acid. Defects in this gene are the cause of long-chain acyl-CoA dehydrogenase (LCAD) deficiency, leading to nonketotic hypoglycemia.
Impaired ACADL activity results in non-ketotic hypoglycemia, hypotonia, muscle weakness and episodes of cardiorespiratory arrest associated with fasting. A number of straight-chain acyl-CoA dehydrogenases of different substrate specificities are present in mammalian tissues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD661Hu01 Recombinant Acyl Coenzyme A Dehydrogenase, Long Chain (ACADL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD661Hu01 Polyclonal Antibody to Acyl Coenzyme A Dehydrogenase, Long Chain (ACADL) WB; IHC; ICC; IP.
Assay Kits SED661Hu ELISA Kit for Acyl Coenzyme A Dehydrogenase, Long Chain (ACADL) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD661Mu01 Recombinant Acyl Coenzyme A Dehydrogenase, Long Chain (ACADL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD661Mu01 Polyclonal Antibody to Acyl Coenzyme A Dehydrogenase, Long Chain (ACADL) WB; IHC; ICC; IP.
Assay Kits SED661Mu ELISA Kit for Acyl Coenzyme A Dehydrogenase, Long Chain (ACADL) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Acyl Coenzyme A Dehydrogenase, Long Chain (ACADL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Acyl Coenzyme A Dehydrogenase, Long Chain (ACADL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Acyl Coenzyme A Dehydrogenase, Long Chain (ACADL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Acyl Coenzyme A Dehydrogenase, Long Chain (ACADL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Acyl Coenzyme A Dehydrogenase, Long Chain (ACADL) ELISA Kit Customized Service Offer
  1. "Molecular cloning and nucleotide sequence of cDNAs encoding human long-chain acyl-CoA dehydrogenase and assignment of the location of its gene (ACADL) to chromosome 2."Genomics 11:609-620(1991) [PubMed] [Europe PMC] [Abstract]
  2. ErratumGenomics 12:626-626(1992) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  7. "The molecular basis of human long chain acyl-CoA dehydrogenase deficiency."Am. J. Hum. Genet. 49:409-409(1991)