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Hydroxyacyl Coenzyme A Dehydrogenase (HADH)

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HADHSC; HADH1; SCHAD; L-3-Hydroxyacyl-Coenzyme A Dehydrogenase,Short Chain; Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase

Hydroxyacyl Coenzyme A Dehydrogenase (HADH)
CCC D682
HGNC 4799
MGI 96009
PubMed 21252247
RGD 69321
UniProt Q16836
Wiki HADH
HADH is a member of the 3-hydroxyacyl-CoA dehydrogenase gene family. The encoded protein functions in the mitochondrial matrix to catalyze the oxidation of straight-chain 3-hydroxyacyl-CoAs as part of the beta-oxidation pathway. Its enzymatic activity is highest with medium-chain-length fatty acids. Mutations in this gene cause one form of familial hyperinsulinemic hypoglycemia. The human genome contains a related pseudogene.Human HADH encodes a deduced 314-amino acid protein composed of a 12-residue mitochondrial import signal peptide and a 302-residue mature HADH protein with a calculated molecular mass of 34.3 kD. The sequence of the mature protein shows 94% identity with HADH from pig heart. Northern blot analysis revealed expression of HADH in liver, kidney, pancreas, heart, and skeletal muscle.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD682Hu01 Recombinant Hydroxyacyl Coenzyme A Dehydrogenase (HADH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD682Hu01 Polyclonal Antibody to Hydroxyacyl Coenzyme A Dehydrogenase (HADH) WB; IHC; ICC; IP.
Assay Kits SED682Hu ELISA Kit for Hydroxyacyl Coenzyme A Dehydrogenase (HADH) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD682Mu01 Recombinant Hydroxyacyl Coenzyme A Dehydrogenase (HADH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD682Mu01 Polyclonal Antibody to Hydroxyacyl Coenzyme A Dehydrogenase (HADH) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Hydroxyacyl Coenzyme A Dehydrogenase (HADH) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hydroxyacyl Coenzyme A Dehydrogenase (HADH) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD682Ra01 Recombinant Hydroxyacyl Coenzyme A Dehydrogenase (HADH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Hydroxyacyl Coenzyme A Dehydrogenase (HADH) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hydroxyacyl Coenzyme A Dehydrogenase (HADH) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hydroxyacyl Coenzyme A Dehydrogenase (HADH) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hydroxyacyl Coenzyme A Dehydrogenase (HADH) ELISA Kit Customized Service Offer
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  8. "Sequestration of the active site by interdomain shifting. Crystallographic and spectroscopic evidence for distinct conformations of L-3-hydroxyacyl-CoA dehydrogenase."J. Biol. Chem. 275:27186-27196(2000) [PubMed] [Europe PMC] [Abstract]
  9. "3-hydroxyacyl-CoA dehydrogenase and short chain 3-hydroxyacyl-CoA dehydrogenase in human health and disease."FEBS J. 272:4874-4883(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Fulminant hepatic failure associated with mutations in the medium and short chain L-3-hydroxyacyl-CoA dehydrogenase gene."J. Inherit. Metab. Dis. 23 Suppl. 1:127-127(2000)
  11. "Hyperinsulinism in short-chain L-3-hydroxyacyl-CoA dehydrogenase deficiency reveals the importance of beta-oxidation in insulin secretion."J. Clin. Invest. 108:457-465(2001) [PubMed] [Europe PMC] [Abstract]