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Diazepam Binding Inhibitor (DBI)

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ACBP; ACBD1; CCK-RP; EP; Endozepine; GABA Receptor Modulator; Acyl-Coenzyme A Binding Protein

Diazepam Binding Inhibitor (DBI)
CCC D696
HGNC 2690
MGI 94865
PubMed 1649940
RGD 2490
UniProt P07108
Wiki DBI
Acyl-CoA-binding protein isa protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor also mediates the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent synthesis of steroids in the adrenal gland.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD696Hu01 Recombinant Diazepam Binding Inhibitor (DBI) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD696Hu01 Polyclonal Antibody to Diazepam Binding Inhibitor (DBI) WB; IHC; ICC; IP.
LAD696Hu71 Biotin-Linked Polyclonal Antibody to Diazepam Binding Inhibitor (DBI) WB; IHC; ICC.
LAD696Hu81 FITC-Linked Polyclonal Antibody to Diazepam Binding Inhibitor (DBI) WB; IHC; ICC; IF.
MAD696Hu21 Monoclonal Antibody to Diazepam Binding Inhibitor (DBI) WB; IHC; ICC; IP.
Assay Kits SED696Hu ELISA Kit for Diazepam Binding Inhibitor (DBI) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD696Mu01 Recombinant Diazepam Binding Inhibitor (DBI) Positive Control; Immunogen; SDS-PAGE; WB.
RPD696Mu02 Recombinant Diazepam Binding Inhibitor (DBI) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD696Mu01 Polyclonal Antibody to Diazepam Binding Inhibitor (DBI) WB; IHC; ICC; IP.
LAD696Mu71 Biotin-Linked Polyclonal Antibody to Diazepam Binding Inhibitor (DBI) WB; IHC; ICC.
PAD696Mu02 Polyclonal Antibody to Diazepam Binding Inhibitor (DBI) WB; IHC; ICC; IP.
Assay Kits SED696Mu ELISA Kit for Diazepam Binding Inhibitor (DBI) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Diazepam Binding Inhibitor (DBI) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Diazepam Binding Inhibitor (DBI) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Diazepam Binding Inhibitor (DBI) Polyclonal Antibody Customized Service Offer
Assay Kits SED696Ra ELISA Kit for Diazepam Binding Inhibitor (DBI) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Cloning and expression of cDNA for human diazepam binding inhibitor, a natural ligand of an allosteric regulatory site of the gamma-aminobutyric acid type A receptor."Proc. Natl. Acad. Sci. U.S.A. 83:7547-7551(1986) [PubMed] [Europe PMC] [Abstract]
  2. "Bovine and human cDNA sequences encoding a putative benzodiazepine receptor ligand."DNA 6:71-79(1987) [PubMed] [Europe PMC] [Abstract]
  3. "Identification of new acyl-CoA binding protein transcripts in human and mouse."Int. J. Biochem. Cell Biol. 37:2395-2405(2005) [PubMed] [Europe PMC] [Abstract]
  4. "Identification of a novel human Acyl-CoA binding protein isoform with a unique C-terminal domain."IUBMB Life 63:547-552(2011) [PubMed] [Europe PMC] [Abstract]
  5. "Specific regulation of low-abundance transcript variants encoding human Acyl-CoA binding protein (ACBP) isoforms."J. Cell. Mol. Med. 15:909-927(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Complete amino acid sequences of bovine and human endozepines. Homology with rat diazepam binding inhibitor."J. Biol. Chem. 261:9727-9731(1986) [PubMed] [Europe PMC] [Abstract]
  9. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Purification and analysis of growth regulating proteins secreted by a human melanoma cell line."Melanoma Res. 2:327-336(1992) [PubMed] [Europe PMC] [Abstract]
  11. "The characterization of two diazepam binding inhibitor (DBI) transcripts in humans."Biochem. J. 306:327-330(1995) [PubMed] [Europe PMC] [Abstract]
  12. "Acyl-CoA-binding protein (ACBP) localizes to the endoplasmic reticulum and Golgi in a ligand-dependent manner in mammalian cells."Biochem. J. 410:463-472(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "The first identification of lysine malonylation substrates and its regulatory enzyme."Mol. Cell. Proteomics 10:M111.012658.01-M111.012658.12(2011) [PubMed] [Europe PMC] [Abstract]
  18. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  19. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  20. "High resolution crystal structures of unliganded and liganded human liver ACBP reveal a new mode of binding for the acyl-CoA ligand."Proteins 66:229-238(2007) [PubMed] [Europe PMC] [Abstract]