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Bisphosphoglycerate Mutase (BPGM)

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2,3-Bisphosphoglycerate Mutase; 2,3-bisphosphoglycerate mutase, erythrocyte; 2,3-bisphosphoglycerate synthase; BPG-dependent PGAM

Bisphosphoglycerate Mutase (BPGM)
CCC D716
HGNC 1093
MGI 1098242
PubMed 1421379
RGD 735018
UniProt P07738
Wiki BPGM
Bisphosphoglycerate mutase (BPGM) is an enzyme unique to erythrocytes and placental cells. It is responsible for the catalytic synthesis of 2,3-Bisphosphoglycerate (2,3-BPG) from 1,3-bisphosphoglycerate. BPGM also has a mutase and a phosphatase function, but these are much less active, in contrast to its glycolitic cousin, phosphoglycerate mutase (PGM), which favors these two functions, but can also catalyze the synthesis of 2,3-BPG to a lesser extent.
Because the main function of bisphosphoglycerate mutase is the synthesis of 2,3-BPG, this enzyme is found only in erythrocytes and placental cells. In glycolysis, converting 1,3-BPG to 2,3-BPG would be very inefficient, as it just adds another unnecessary step.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD716Hu01 Recombinant Bisphosphoglycerate Mutase (BPGM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD716Hu01 Polyclonal Antibody to Bisphosphoglycerate Mutase (BPGM) WB; IHC; ICC; IP.
Assay Kits SED716Hu ELISA Kit for Bisphosphoglycerate Mutase (BPGM) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD716Mu01 Recombinant Bisphosphoglycerate Mutase (BPGM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD716Mu01 Polyclonal Antibody to Bisphosphoglycerate Mutase (BPGM) WB; IHC; ICC; IP.
Assay Kits SED716Mu ELISA Kit for Bisphosphoglycerate Mutase (BPGM) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bisphosphoglycerate Mutase (BPGM) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bisphosphoglycerate Mutase (BPGM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bisphosphoglycerate Mutase (BPGM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bisphosphoglycerate Mutase (BPGM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bisphosphoglycerate Mutase (BPGM) ELISA Kit Customized Service Offer
  1. "Isolation, characterization, and structure of a mutant 89 ArgTO: bisphosphoglycerate mutase. Implication of the active site in the mutation."J. Biol. Chem. 264:7837-7843(1989) [PubMed] [Europe PMC] [Abstract]
  2. "The complete amino acid sequence of human erythrocyte diphosphoglycerate mutase."EMBO J. 2:1213-1220(1983) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning and sequencing of the human erythrocyte 2,3-bisphosphoglycerate mutase cDNA: revised amino acid sequence."EMBO J. 5:2275-2283(1986) [PubMed] [Europe PMC] [Abstract]
  4. "Molecular cloning of the human 2,3-bisphosphoglycerate mutase cDNA and revised amino acid sequence."Biomed. Biochim. Acta 46:S126-S130(1987) [PubMed] [Europe PMC] [Abstract]
  5. "Isolation and characterization of the human 2,3-bisphosphoglycerate mutase gene."J. Biol. Chem. 263:15785-15790(1988) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Human erythrocyte bisphosphoglycerate mutase: inactivation by glycation in vivo and in vitro."J. Biochem. 124:1237-1244(1998) [PubMed] [Europe PMC] [Abstract]
  10. "The platelet-activating factor acetylhydrolase from human erythrocytes. Purification and properties."J. Biol. Chem. 268:3857-3865(1993) [PubMed] [Europe PMC] [Abstract]
  11. "Model of 2,3-bisphosphoglycerate metabolism in the human erythrocyte based on detailed enzyme kinetic equations: equations and parameter refinement."Biochem. J. 342:581-596(1999) [PubMed] [Europe PMC] [Abstract]
  12. "Novel placental expression of 2,3-bisphosphoglycerate mutase."Placenta 27:924-927(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Structural modeling of the human erythrocyte bisphosphoglycerate mutase."Biochimie 74:519-526(1992) [PubMed] [Europe PMC] [Abstract]
  17. "Seeing the process of histidine phosphorylation in human bisphosphoglycerate mutase."J. Biol. Chem. 281:39642-39648(2006) [PubMed] [Europe PMC] [Abstract]
  18. "Unliganded structure of human bisphosphoglycerate mutase reveals side-chain movements induced by ligand binding."Acta Crystallogr. F 66:1415-1420(2010) [PubMed] [Europe PMC] [Abstract]
  19. "Compound heterozygosity in a complete erythrocyte bisphosphoglycerate mutase deficiency."Blood 80:2643-2649(1992) [PubMed] [Europe PMC] [Abstract]
  20. "Erythrocytosis due to bisphosphoglycerate mutase deficiency with concurrent glucose-6-phosphate dehydrogenase (G-6-PD) deficiency."Am. J. Hematol. 75:205-208(2004) [PubMed] [Europe PMC] [Abstract]