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Apolipoprotein O (APOO)

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Apo-O; FAM121B; My025; Family With Sequence Similarity 121B

Apolipoprotein O (APOO)
CCC D742
HGNC 28727
MGI 1915566
PubMed 22693255
UniProt Q9BUR5
Wiki APOO
ApoO is a member of the apolipoprotein family. Members of this protein family are involved in the transport and metabolism of lipids. The encoded protein associates with HDL, LDL and VLDL lipoproteins and is characterized by chondroitin-sulfate glycosylation. This protein may be involved in preventing lipid accumulation in the myocardium in obese and diabetic patients. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 4, 5, 12 and 16.Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL. May be involved in myocardium-protective mechanisms against lipid accumulation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD742Hu01 Recombinant Apolipoprotein O (APOO) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD742Hu01 Polyclonal Antibody to Apolipoprotein O (APOO) WB
MAD742Hu21 Monoclonal Antibody to Apolipoprotein O (APOO) WB; IHC; ICC; IP.
Assay Kits SED742Hu ELISA Kit for Apolipoprotein O (APOO) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Apolipoprotein O (APOO) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Apolipoprotein O (APOO) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Apolipoprotein O (APOO) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Apolipoprotein O (APOO) CLIA Kit Customized Service Offer
n/a ELISA Kit for Apolipoprotein O (APOO) ELISA Kit Customized Service Offer
  1. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "ApoO, a novel apolipoprotein, is an original glycoprotein up-regulated by diabetes in human heart."J. Biol. Chem. 281:36289-36302(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]