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Runt Related Transcription Factor 3 (RUNX3)

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AML2; CBFA3; PEBP2aC; PEBP2A3; Acute myeloid leukemia 2 protein; Core-binding factor subunit alpha-3; Polyomavirus enhancer-binding protein 2 alpha C subunit

Runt Related Transcription Factor 3 (RUNX3)
CCC D749
HGNC 10473
MGI 102672
PubMed 14765120
RGD 620082
UniProt Q13761
Wiki RUNX3
RUNX3 is a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
Runx3 null mouse gastric mucosa exhibits hyperplasia due to stimulated proliferation and suppressed apoptosis in epithelial cells, and the cells are resistant to TGF-beta stimulation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Runt Related Transcription Factor 3 (RUNX3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Runt Related Transcription Factor 3 (RUNX3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Runt Related Transcription Factor 3 (RUNX3) Polyclonal Antibody Customized Service Offer
Assay Kits SED749Hu ELISA Kit for Runt Related Transcription Factor 3 (RUNX3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD749Mu01 Recombinant Runt Related Transcription Factor 3 (RUNX3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD749Mu01 Polyclonal Antibody to Runt Related Transcription Factor 3 (RUNX3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Runt Related Transcription Factor 3 (RUNX3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Runt Related Transcription Factor 3 (RUNX3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Runt Related Transcription Factor 3 (RUNX3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Runt Related Transcription Factor 3 (RUNX3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Runt Related Transcription Factor 3 (RUNX3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Runt Related Transcription Factor 3 (RUNX3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Runt Related Transcription Factor 3 (RUNX3) ELISA Kit Customized Service Offer
  1. "Cloning, mapping and expression of PEBP2 alpha C, a third gene encoding the mammalian Runt domain."Gene 159:245-248(1995) [PubMed] [Europe PMC] [Abstract]
  2. "AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization."Genomics 23:425-432(1994) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of a new murine runt domain-containing gene, Cbfa3, and localization of the human homolog, CBFA3, to chromosome 1p35-pter."Genomics 26:611-614(1995) [PubMed] [Europe PMC] [Abstract]
  6. "Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors."Proc. Natl. Acad. Sci. U.S.A. 95:11590-11595(1998) [PubMed] [Europe PMC] [Abstract]
  7. "RUNX1 associates with histone deacetylases and SUV39H1 to repress transcription."Oncogene 25:5777-5786(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1."Nature 446:685-689(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm."J. Biol. Chem. 285:10122-10129(2010) [PubMed] [Europe PMC] [Abstract]