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Runt Related Transcription Factor 1 (RUNX1)

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AML1; AMLCR1; CBFA2; EVI-1; PEBP2aB; Acute Myeloid Leukemia 1; Aml1 Oncogene; Core-binding factor subunit alpha-2; Polyomavirus enhancer-binding protein 2 alpha B subunit

Runt Related Transcription Factor 1 (RUNX1)
CCC D750
HGNC 10471
MGI 99852
PubMed 21343560
RGD 2283
UniProt Q01196
Wiki RUNX1
RUNX1 is an eukaryotic gene and the protein encoded by this gene is a transcription factor associated with M2 AML, a type of leukemia. It belongs to the Runt-related transcription factor (RUNX) family of genes which are also called core binding factor-α (CBFα). RUNX proteins form a heterodimeric complex with CBFβ which confers increased DNA binding and stability to the complex. RUNX1 is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Two transcript variants encoding different isoforms have been found for this gene. The consensus binding site for CBF has been identified to be a 7 bp sequence PyGPyGGTPy. Py denotes pyrimidine which can be either cytosine or thymine.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD750Hu01 Recombinant Runt Related Transcription Factor 1 (RUNX1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD750Hu01 Polyclonal Antibody to Runt Related Transcription Factor 1 (RUNX1) WB; IHC; ICC; IP.
Assay Kits SED750Hu ELISA Kit for Runt Related Transcription Factor 1 (RUNX1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Runt Related Transcription Factor 1 (RUNX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Runt Related Transcription Factor 1 (RUNX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Runt Related Transcription Factor 1 (RUNX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Runt Related Transcription Factor 1 (RUNX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Runt Related Transcription Factor 1 (RUNX1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Runt Related Transcription Factor 1 (RUNX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Runt Related Transcription Factor 1 (RUNX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Runt Related Transcription Factor 1 (RUNX1) Polyclonal Antibody Customized Service Offer
Assay Kits SED750Ra ELISA Kit for Runt Related Transcription Factor 1 (RUNX1) Enzyme-linked immunosorbent assay for Antigen Detection.
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