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Preprovasopressin (VP)

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AVP-NPII; ARVP; AVP; Vasopressin-Neurophysin 2-Copeptin; Arginine-vasopressin; Neurophysin 2; Copeptin

Preprovasopressin (VP)
CCC D766
HGNC 894
MGI 88121
PubMed 15070970
RGD 2184
UniProt P01185
AVP-NPII encodes a precursor protein consisting of arginine vasopressin and two associated proteins, neurophysin II and a glycopeptide, copeptin. Arginine vasopressin is a posterior pituitary hormone which is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin II, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. The precursor is thought to be activated while it is being transported along the axon to the posterior pituitary. Arginine vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. It has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD766Hu01 Recombinant Preprovasopressin (VP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD766Hu01 Polyclonal Antibody to Preprovasopressin (VP) WB; IHC; ICC; IP.
Assay Kits SED766Hu ELISA Kit for Preprovasopressin (VP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD766Mu01 Recombinant Preprovasopressin (VP) Positive Control; Immunogen; SDS-PAGE; WB.
RPD766Mu02 Recombinant Preprovasopressin (VP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD766Mu01 Polyclonal Antibody to Preprovasopressin (VP) WB; IHC; ICC; IP.
LAD766Mu71 Biotin-Linked Polyclonal Antibody to Preprovasopressin (VP) WB; IHC; ICC.
PAD766Mu02 Polyclonal Antibody to Preprovasopressin (VP) WB; IHC; ICC; IP.
Assay Kits SED766Mu ELISA Kit for Preprovasopressin (VP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD766Ra01 Recombinant Preprovasopressin (VP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD766Ra01 Polyclonal Antibody to Preprovasopressin (VP) WB; IHC; ICC; IP.
LAD766Ra71 Biotin-Linked Polyclonal Antibody to Preprovasopressin (VP) WB; IHC; ICC.
Assay Kits SED766Ra ELISA Kit for Preprovasopressin (VP) Enzyme-linked immunosorbent assay for Antigen Detection.
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  11. "Glu-47, which forms a salt bridge between neurophysin-II and arginine vasopressin, is deleted in patients with familial central diabetes insipidus."J. Clin. Endocrinol. Metab. 77:600-604(1993) [PubMed] [Europe PMC] [Abstract]
  12. "Possible involvement of inefficient cleavage of preprovasopressin by signal peptidase as a cause for familial central diabetes insipidus."J. Clin. Invest. 91:2565-2571(1993) [PubMed] [Europe PMC] [Abstract]
  13. "A de novo mutation in the coding sequence for neurophysin-II (Pro24-->Leu) is associated with onset and transmission of autosomal dominant neurohypophyseal diabetes insipidus."J. Clin. Endocrinol. Metab. 79:421-427(1994) [PubMed] [Europe PMC] [Abstract]
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  16. "Autosomal dominant neurohypophyseal diabetes insipidus associated with a missense mutation encoding Gly23-->Val in neurophysin II."J. Clin. Endocrinol. Metab. 82:3643-3646(1997) [PubMed] [Europe PMC] [Abstract]
  17. "Identification of a novel nonsense mutation and a missense substitution in the vasopressin-neurophysin II gene in two Spanish kindreds with familial neurohypophyseal diabetes insipidus."J. Clin. Endocrinol. Metab. 83:995-997(1998) [PubMed] [Europe PMC] [Abstract]
  18. "Two novel mutations of the vasopressin gene associated with familial diabetes insipidus and identification of an asymptomatic carrier infant."J. Clin. Endocrinol. Metab. 83:3958-3964(1998) [PubMed] [Europe PMC] [Abstract]
  19. "Autosomal recessive familial neurohypophyseal diabetes insipidus with continued secretion of mutant weakly active vasopressin."Hum. Mol. Genet. 8:1303-1307(1999) [PubMed] [Europe PMC] [Abstract]
  20. "Molecular analysis in familial neurohypophyseal diabetes insipidus: early diagnosis of an asymptomatic carrier."J. Clin. Endocrinol. Metab. 84:3351-3354(1999) [PubMed] [Europe PMC] [Abstract]
  21. "Identification of two distinct mutations at the same nucleotide position, concomitantly with a novel polymorphism in the vasopressin-neurophysin II gene (AVP-NP II) in two Dutch families with familial neurohypophyseal diabetes insipidus."Clin. Chem. 46:1699-1702(2000) [PubMed] [Europe PMC] [Abstract]
  22. "A novel arginine vasopressin-neurophysin II mutation causes autosomal dominant neurohypophyseal diabetes insipidus and morphologic pituitary changes."Horm. Res. 53:239-245(2000) [PubMed] [Europe PMC] [Abstract]
  23. "Familial neurohypophyseal diabetes insipidus associated with a novel mutation in the vasopressin-neurophysin II gene."Int. J. Mol. Med. 5:229-234(2000) [PubMed] [Europe PMC] [Abstract]
  24. "A new mutation of the arginine vasopressin-neurophysin II gene in a family with autosomal dominant neurohypophyseal diabetes insipidus."Exp. Clin. Endocrinol. Diabetes 109:406-409(2001) [PubMed] [Europe PMC] [Abstract]
  25. "Familial neurohypophysial diabetes insipidus in a large Dutch kindred: effect of the onset of diabetes on growth in children and cell biological defects of the mutant vasopressin prohormone."J. Clin. Endocrinol. Metab. 86:3410-3420(2001) [PubMed] [Europe PMC] [Abstract]
  26. "A missense mutation encoding cys(67) --> gly in neurophysin ii is associated with early onset autosomal dominant neurohypophyseal diabetes insipidus."Mol. Genet. Metab. 72:39-44(2001) [PubMed] [Europe PMC] [Abstract]
  27. "Clinical and molecular analysis of three families with autosomal dominant neurohypophyseal diabetes insipidus associated with a novel and recurrent mutations in the vasopressin-neurophysin II gene."Eur. J. Endocrinol. 146:649-656(2002) [PubMed] [Europe PMC] [Abstract]
  28. "Identification of a novel mutation in the arginine vasopressin-neurophysin II gene in familial central diabetes insipidus."Exp. Clin. Endocrinol. Diabetes 110:134-137(2002) [PubMed] [Europe PMC] [Abstract]
  29. "Autosomal dominant neurohypophyseal diabetes insipidus due to substitution of histidine for tyrosine-2 in the vasopressin moiety of the hormone precursor."J. Clin. Endocrinol. Metab. 87:3351-3355(2002) [PubMed] [Europe PMC] [Abstract]
  30. "A missense mutation encoding Cys73Phe in neurophysin II is associated with autosomal dominant neurohypophyseal diabetes insipidus."Mol. Genet. Metab. 77:112-118(2002) [PubMed] [Europe PMC] [Abstract]
  31. "A signal peptide mutation of the arginine vasopressin gene in monozygotic twins."Clin. Endocrinol. (Oxf.) 58:108-110(2003) [PubMed] [Europe PMC] [Abstract]
  32. "Progressive decline of vasopressin secretion in familial autosomal dominant neurohypophyseal diabetes insipidus presenting a novel mutation in the vasopressin-neurophysin II gene."Clin. Endocrinol. (Oxf.) 59:511-518(2003) [PubMed] [Europe PMC] [Abstract]
  33. "A new missense mutation of the vasopressin-neurophysin II gene in a family with neurohypophyseal diabetes insipidus."Horm. Res. 60:143-147(2003) [PubMed] [Europe PMC] [Abstract]
  34. "Identification of a novel mutation in the arginine vasopressin-neurophysin II gene affecting the sixth intrachain disulfide bridge of the neurophysin II moiety."Eur. J. Endocrinol. 151:605-611(2004) [PubMed] [Europe PMC] [Abstract]
  35. "Six novel mutations in the arginine vasopressin gene in 15 kindreds with autosomal dominant familial neurohypophyseal diabetes insipidus give further insight into the pathogenesis."Eur. J. Hum. Genet. 12:44-51(2004) [PubMed] [Europe PMC] [Abstract]